Post-COVID-19 fatigue : the contribution of cognitive and neuropsychiatric symptoms
Calabria, Marco (Universitat Oberta de Catalunya. Estudis de Ciències de la Salut)
García-Sánchez, Carmen (Institut d'Investigació Biomèdica Sant Pau)
Grunden, Nicholas (Centre for Research On Brain. Language & Music)
Pons, Catalina (Universitat Ramon Llull. Facultat de Psicologia, Ciències de l'Educació i l'Esport. Blanquerna.)
Arroyo, Juan Antonio (Institut d'Investigació Biomèdica Sant Pau)
Gómez-Ansón, Beatriz (Institut d'Investigació Biomèdica Sant Pau)
Estévez García, Marina del Carmen (Hospital de la Santa Creu i Sant Pau (Barcelona, Catalunya))
Belvís, Roberto (Hospital de la Santa Creu i Sant Pau (Barcelona, Catalunya))
Morollón, Noemí (Hospital de la Santa Creu i Sant Pau (Barcelona, Catalunya))
Vera Igual, Javier (Hospital de la Santa Creu i Sant Pau (Barcelona, Catalunya))
Mur, Isabel (Institut d'Investigació Biomèdica Sant Pau)
Pomar, Virginia (Institut d'Investigació Biomèdica Sant Pau)
Domingo, Pere (Institut d'Investigació Biomèdica Sant Pau)
Universitat Autònoma de Barcelona

Date:	2022
Abstract:	Fatigue in its many forms of physical, mental, and psychosocial exhaustion is a common symptom of post-COVID-19 condition, also known as "Long COVID. " Persistent fatigue in COVID-19 patients is frequently accompanied by cognitive dysfunction and neuropsychiatric symptoms; however, less is known about the relationships between these components of post-COVID-19 condition and fatigue itself. Consequently, the present study sought to (1) distinguish the types of fatigue experienced by participants, and (2) investigate whether cognitive deficits across various domains and neuropsychiatric conditions predicted these different types of fatigue. The study included 136 COVID-19 patients referred for neuropsychological evaluation due to cognitive complaints 8 months on average after SARS-CoV-2 infection. Measures included self-reported fatigue (physical, cognitive, and psychosocial), neuropsychiatric questionnaires (assessing symptoms of depression, anxiety, apathy, and executive functioning), a comprehensive neuropsychological assessment, and self-reported quality of life and everyday functioning. Results showed that reports of clinical significant fatigue were pervasive in our sample (82. 3% of participants), with physical fatigue rated highest on average relative to the subscale maximum. Elevated levels of apathy, anxiety, and executive dysfunction in neuropsychiatric measures along with executive and attentional difficulties on cognitive tests were found to be consistently important predictors among different types of fatigue. This implicates both cognitive and neuropsychiatric symptoms as predictors of fatigue in post-COVID-19 condition, and stresses the importance of a holistic approach in assessing and considering potential treatment for COVID-19 patients experiencing fatigue.
Rights:	Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original.
Language:	Anglès
Document:	Article ; recerca ; Versió publicada
Subject:	COVID-19 ; Fatigue ; Cognitive complaints ; Neuropsychiatric symptoms ; Neuropsychology
Published in:	Journal of Neurology, Vol. 269 Núm. 8 (august 2022) , p. 3990-3999, ISSN 1432-1459

DOI: 10.1007/s00415-022-11141-8
PMID: 35488918

10 p, 709.5 KB

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Research literature > UAB research groups literature > Research Centres and Groups (research output) > Health sciences and biosciences > Institut de Recerca Sant Pau
Articles > Research articles
Articles > Published articles