Systematic Review of Systemic Corticosteroids for Treatment of Organizing Pneumonia Revisión sistemática de los corticosteroides para el tratamiento de la neumonía organizativa
Cendon, L. (Institut d'Investigació Biomèdica Sant Pau)
Rafecas-Codern, Albert (Institut d'Investigació Biomèdica Sant Pau)
de la Rosa Carrillo, David (Institut d'Investigació Biomèdica Sant Pau)
Castellvi, Ivan (Institut d'Investigació Biomèdica Sant Pau)
Spagnolo, P. (Respiratory Disease Unit. Department of Cardiac. Thoracic. Vascular Sciences and Public Health. University of Padova)
Castillo, Diego (Institut d'Investigació Biomèdica Sant Pau)

Date:	2022
Abstract:	Introduction: Regardless corticosteroids are recommended for the treatment of organizing pneumonia there is limited evidence supporting this practice. Thus, we performed a systematic review of the literature on systemic corticosteroid treatment for organizing pneumonia. Methods: A search was implemented in the PubMed database (Medline) for articles published in the last 20 years. Those studies with incomplete or insufficient data and case reports were excluded. We collected data including: demographics, clinical data, diagnostic procedures, aetiology, treatment regimen (drug, posology, duration, response) and evolution. Results: A total of 135 publications were selected and finally 13 studies with 849 patients were included in the review: 12 retrospective observational studies and a single prospective observational study. Most of the patients were started on treatment with systemic corticosteroids - a total of 627 (30-100% depending on the series), but there was a great heterogeneity regarding drug, doses and duration. On those that started treatment, 226 (36%) presented a relapse of the disease during follow-up. Only one study provided information regarding treatment side-effects. Conclusion: The findings of this systematic review show the low quality data supporting the use of corticosteroids for the treatment of organizing pneumonia. This highlights a need to undertake appropriately designed studies to investigate which is the most appropriate treatment regimen that trades off benefits and risks of prolonged corticosteroid administration.
Rights:	Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució i la comunicació pública de l'obra, sempre que es reconegui l'autoria de l'obra original. No es permet la creació d'obres derivades.
Language:	Castellà
Document:	Article ; recerca ; Versió publicada
Published in:	Open Respiratory Archives, Vol. 4 Núm. 4 (enero 2022) , p. 100211, ISSN 2659-6636

DOI: 10.1016/j.opresp.2022.100211
PMID: 37496960

8 p, 960.5 KB

The record appears in these collections:
Research literature > UAB research groups literature > Research Centres and Groups (research output) > Health sciences and biosciences > Institut de Recerca Sant Pau
Articles > Research articles
Articles > Published articles