KL-6 in ANCA-Associated Vasculitis Patients with and without ILD : A Machine Learning Approach
Conticini, E. (University of Siena. Department of Medicine. Surgery & Neurosciences)
D'Alessandro, M (University of Siena. Department of Medicine. Surgery & Neurosciences)
Bergantini, L. (University of Siena. Department of Medicine. Surgery & Neurosciences)
Castillo, Diego (Institut d'Investigació Biomèdica Sant Pau)
Cameli, Paolo (University of Siena. Department of Medicine. Surgery & Neurosciences)
Frediani, B. (University of Siena. Department of Medicine. Surgery & Neurosciences)
Cantarini, L. (University of Siena. Department of Medicine. Surgery & Neurosciences)
Bargagli, E. (University of Siena. Department of Medicine. Surgery & Neurosciences)

Data:	2022
Resum:	Background: ANCA-associated vasculitis (AAV) are small vessel vasculitis distinguished between microscopic polyangiitis (MPA) and granulomatosis with polyangiitis (GPA). The former may have interstitial lung disease (ILD) associated with high morbidity and mortality. Here, Krebs von den Lungen-6 (KL-6), a marker of fibrotic ILD, was assessed for distinguishing AAV patients with ILD from those without ILD, and whether its changes over time are correlated with disease activity. Materials and Methods: Thirteen AAV patients (eight females, mean age 61 ± 14. 8 years) were enrolled: six MPA and six GPA. Serum samples were assayed for KL-6 concentrations (Fujirebio Europe, Belgium). To investigate potential binary classifiers for diagnosis of AAV-ILD, we constructed a regression decision tree model. Results: Higher serum KL-6 were in AAV-ILD compared with those without ILD (972. 8 ± 398. 5 vs 305. 4 ± 93. 9, p = 0. 0040). Area under the receiver operating characteristics curve showed 100% of the diagnostic performance of KL-6 for identifying the ILD involvement (accuracy 91. 7%) and the best cutoff value of 368 U/mL (sensitivity 100% and specificity 87. 5%). The decision tree model showed a 33% improvement in class purity using a cut-off value of 513 U/mL to distinguish AAV patients with and without ILD. Stratifying AAV patients as MPA and GPA with and without ILD considering T0 and T1 KL-6, the model obtained an improvement of 40% for classifying GPA non-ILD with a T0 serum KL-6 cut-off value of 513 U/mL and a T1 KL-6 cut-off of 301 U/mL. A direct correlation was found between serum T0 KL-6 and T0 BVAS (r = 0. 578, p = 0. 044). Conclusion: Our multicenter study demonstrated KL-6 as a reliable, non-invasive, and easy-to-perform marker of ILD in AAV patients and its helpfulness for disease activity assessment. Changes in serum concentrations of KL-6 over time could be useful for monitoring AAV patients. Further study of KL-6 as a marker of response to therapy during long-term follow-up would also be worthwhile.
Drets:	Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original.
Llengua:	Anglès
Document:	Article ; recerca ; Versió publicada
Matèria:	KL-6 ; ANCA-associated vasculitis ; Interstitial lung disease
Publicat a:	Biology, Vol. 11 Núm. 1 (january 2022) , p. 94, ISSN 2079-7737

DOI: 10.3390/biology11010094
PMID: 35053092

10 p, 1.5 MB

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