Results of haploidentical transplant in patients with donor-specific antibodies : a survey on behalf of the Spanish Group of Hematopoietic Transplant and Cell Therapy
Bailén, Rebeca (Hospital General Universitario Gregorio Marañón)
Alenda, Raquel (Centro de Transfusión de la Comunidad de Madrid)
Herruzo-Delgado, Beatriz (Hospital Regional Universitario de Málaga)
Acosta-Fleitas, Cynthia (Hospital Universitario de Gran Canaria Dr. Negrín)
Vallés, Ana (Hospital Universitario Ramón y Cajal (Madrid))
Esquirol, Albert (Institut d'Investigació Biomèdica Sant Pau)
Fonseca, Marta (Hospital Clínico Universitario (Salamanca))
Solán, Laura (Hospital Universitario Fundación Jiménez Díaz)
Sánchez-Vadillo, Irene (Hospital Universitario La Paz (Madrid))
Bautista, Guiomar (Hospital Universitario Puerta de Hierro Majadahonda (Madrid))
Bento, Leyre (Hospital Universitari Son Espases (Palma de Mallorca, Balears))
López-Godino, Oriana (Hospital General Universitario Morales Meseguer (Múrcia))
Pérez-Martínez, Ariadna (Hospital Clínic Universitari (València))
Torrent Catarineu, Anna (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras)
Zanabili, Joud (Hospital Universitario Central de Asturias)
Calbacho, Maria (Hospital Universitario 12 de Octubre (Madrid))
Moreno, Miguel Ángel (Centro de Transfusión de la Comunidad de Madrid)
Pascual-Cascón, María Jesús (Hospital Regional Universitario de Málaga)
Guerra-Domínguez, Luisa (Hospital Universitario de Gran Canaria Dr. Negrín)
Chinea, Anabelle (Hospital Universitario Ramón y Cajal (Madrid))
García Cadenas, Irene (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras)
López-Corral, Lucía (Hospital Clínico Universitario (Salamanca))
Boix, Francisco (Universidad de Salamanca)
López Lorenzo, José Luis (Hospital Universitario Fundación Jiménez Díaz)
Humala, Karem (Hospital Universitario La Paz (Madrid))
Duarte, Rafael (Hospital Universitario Puerta de Hierro Majadahonda (Madrid))
Sampol, Antonia (Hospital Universitari Son Espases (Palma de Mallorca, Balears))
Heras, Inmaculada (Hospital General Universitario Morales Meseguer (Múrcia))
Vicario, José Luis (Centro de Transfusión de la Comunidad de Madrid)
Balas, Antonio (Centro de Transfusión de la Comunidad de Madrid)
Oarbeascoa, Gillen (Hospital General Universitario Gregorio Marañón)
Fernández-Caldas, Paula (Hospital General Universitario Gregorio Marañón)
Anguita, Javier (Universidad Complutense de Madrid)
Kwon, Mi (Universidad Complutense de Madrid)
Universitat Autònoma de Barcelona

Date:	2023
Abstract:	Donor-specific antibodies (DSAs) are IgG allo-antibodies against mismatched donor HLA molecules and can cause graft failure (GF) in the setting of haploidentical hematopoietic stem cell transplantation (haplo-HSCT). Our aim was to report the experience of the Spanish Group of Hematopoietic Transplant (GETH-TC) in DSA-positive patients who had undergone haplo-HSCT. We conducted a survey of patients who underwent haplo-HSCT in GETH-TC centers between 2012 and 2021. Data were collected on the DSA assay used, monitoring strategy, complement fixation, criteria for desensitization, desensitization strategies and transplant outcomes. Fifteen centers from the GETH-TC responded to the survey. During the study period, 1,454 patients underwent haplo-HSCT. Seventy of the transplants were performed in 69 DSA-positive patients, all of whom lacked a suitable alternative donor; 61 (88%) patients were female (90% with prior pregnancies). All patients received post-transplant cyclophosphamide-based graft-versus-host disease prophylaxis. Regarding baseline DSA intensity, 46 (67%) patients presented mean fluorescence intensity (MFI).
Rights:	Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original.
Language:	Anglès
Document:	Article ; recerca ; Versió publicada
Subject:	DSA kinetics ; Desensitization strategies ; Donor-specific antibodies ; Graft failure ; Haplo-hsct
Published in:	Frontiers in immunology, Vol. 14 (may 2023) , ISSN 1664-3224

DOI: 10.3389/fimmu.2023.1165759
PMID: 37304258

13 p, 3.3 MB

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Research literature > UAB research groups literature > Research Centres and Groups (research output) > Health sciences and biosciences > Institut d'Investigació en Ciencies de la Salut Germans Trias i Pujol (IGTP) > Josep Carreras Leukaemia Research Institute
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Articles > Published articles