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| Home > Articles > Published articles > Neural plasticity of the uterus : |
(Institut d'Investigació Biomèdica Sant Pau) (Institut d'Investigació Biomèdica Sant Pau) (Institut d'Investigació Biomèdica Sant Pau) (Institut d'Investigació Biomèdica Sant Pau) (Institut d'Investigació Biomèdica Sant Pau) (Institut d'Investigació Biomèdica Sant Pau) (Institut d'Investigació Biomèdica Sant Pau)| Date: | 2022 |
| Abstract: | Endometrial carcinoma is the most common gynecological malignancy in Western countries and is expected to increase in the following years because of the high index of obesity in the population. Recently, neural signaling has been recognized as part of the tumor microenvironment, playing an active role in tumor progression and invasion of different solid tumor types. The uterus stands out for the physiological plasticity of its peripheral nerves due to cyclic remodeling brought on by estrogen and progesterone hormones throughout the reproductive cycle. Therefore, a precise understanding of nerve-cancer crosstalk and the contribution of the organ-intrinsic neuroplasticity, mediated by estrogen and progesterone, of the uterine is urgently needed. The development of new and innovative medicines for patients with endometrial cancer would increase their quality of life and health. This review compiles information on the architecture and function of autonomous uterine neural innervations and the influence of hormone-dependent nerves in normal uterus and tumor progression. It also explores new therapeutic possibilities for endometrial cancer using these endocrine and neural advantages. |
| Grants: | Instituto de Salud Carlos III PI17/00150 Instituto de Salud Carlos III PI20/00623 Instituto de Salud Carlos III CPII20/00007 Agència de Gestió d'Ajuts Universitaris i de Recerca 2017SGR1267 |
| Note: | Altres ajuts: European Regional Development Fund (FEDER); FMMA grant (AP166942017); European Social Fund (ESF 'Investing in Your Future'). |
| Rights: | Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, sempre que no sigui amb finalitats comercials, i sempre que es reconegui l'autoria de l'obra original.  |
| Language: | Anglès |
| Document: | Article de revisió ; recerca ; Versió publicada |
| Subject: | Autonomic nervous system ; Endometrial cancer ; Nerve-cancer ; Nerve plasticity ; Neuroreceptor ; Neurotherapy ; Neurotransmitter ; Sex hormones signaling |
| Published in: | Women's Health, Vol. 18 (april 2022) , ISSN 1745-5065 |
