Allergen sensitization stratifies IL-31 production by memory T cells in atopic dermatitis patients
Sans-de San Nicolàs, Lídia (Universitat de Barcelona. Departament de Biologia Cel·lular, Fisiologia i Immunologia)
Figueras-Nart, Ignasi (Hospital Universitari de Bellvitge)
García-Jiménez, Irene (Universitat de Barcelona. Departament de Biologia Cel·lular, Fisiologia i Immunologia)
Bonfill-Ortí, Montserrat (Hospital Universitari de Bellvitge)
Guilabert, Antonio (Hospital General de Granollers)
Curto-Barredo, Laia (Institut Hospital del Mar d'Investigacions Mèdiques)
Bertolin Colilla, Marta (Institut Hospital del Mar d'Investigacions Mèdiques)
Ferran, Marta (Institut Hospital del Mar d'Investigacions Mèdiques)
Serra Baldrich, Esther (Institut d'Investigació Biomèdica Sant Pau)
Pujol Vallverdú, Ramón M. (Institut Hospital del Mar d'Investigacions Mèdiques)
Santamaria-Babí, Luis F. (Universitat de Barcelona. Departament de Biologia Cel·lular, Fisiologia i Immunologia)
Universitat Autònoma de Barcelona

Date:	2023
Abstract:	The role of allergen sensitization in IL-31 production by T cells and specifically in the clinical context of atopic dermatitis (AD) has not been characterized. The response to house dust mite (HDM) in purified memory T cells cocultured with epidermal cells from AD patients (n=58) and control subjects (n=11) was evaluated. AD-associated cytokines from culture supernatants, plasma proteins and mRNA expression from cutaneous lesions were assessed and related with the clinical features of the patients. HDM-induced IL-31 production by memory T cells defined two subsets of AD patients according to the presence or absence of IL-31 response. Patients in the IL-31 producing group showed a more inflammatory profile, and increased HDM-specific (sp) and total IgE levels compared to the IL-31 non-producing group. A correlation between IL-31 production and patient's pruritus intensity, plasma CCL27 and periostin was detected. When the same patients were analyzed based on sp IgE and total IgE levels, an increased IL-31 in vitro response, as well as type 2 markers in plasma and cutaneous lesions, was found in patients with sp IgE levels.
Grants:	Instituto de Salud Carlos III PI21/01179 Instituto de Salud Carlos III PI21/00335
Rights:	Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original.
Language:	Anglès
Document:	Article ; recerca ; Versió publicada
Subject:	Atopic dermatitis ; CCL27 ; CLA + memory T cells ; House dust mite ; IgE ; IL-31 ; Periostin ; Pruritus
Published in:	Frontiers in immunology, Vol. 14 (march 2023) , ISSN 1664-3224

DOI: 10.3389/fimmu.2023.1124018
PMID: 36993985

12 p, 2.9 MB

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Research literature > UAB research groups literature > Research Centres and Groups (research output) > Health sciences and biosciences > Institut de Recerca Sant Pau
Articles > Research articles
Articles > Published articles