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| Pàgina inicial > Articles > Articles publicats > Mendelian randomization analysis for attention deficit/hyperactivity disorder : |
(Hospital Universitari Vall d'Hebron) (Hospital Universitari Vall d'Hebron. Institut de Recerca) (Hospital Universitari Vall d'Hebron. Institut de Recerca) (Hospital Universitari Vall d'Hebron. Institut de Recerca) (Hospital Universitari Vall d'Hebron. Institut de Recerca) (Hospital Universitari Vall d'Hebron. Institut de Recerca)| Data: | 2022 |
| Resum: | Attention deficit/hyperactivity disorder (ADHD) is a highly prevalent neurodevelopmental disorder caused by a combination of genetic and environmental factors and is often thought as an entry point into a negative life trajectory, including risk for comorbid disorders, poor educational achievement or low income. In the present study, we aimed to clarify the causal relationship between ADHD and a comprehensive range of related traits. We used genome-wide association study (GWAS) summary statistics for ADHD (n = 53 293) and 124 traits related to anthropometry, cognitive function and intelligence, early life exposures, education and employment, lifestyle and environment, longevity, neurological, and psychiatric and mental health or personality and psychosocial factors available in the MR-Base database (16 067 ≤ n ≤766 345). To investigate their causal relationship with ADHD, we used two-sample Mendelian randomization (MR) with a range of sensitivity analyses, and validated MR findings using causal analysis using summary effect estimates (CAUSE), aiming to avoid potential false-positive results. Our findings strengthen previous evidence of a causal effect of ADHD liability on smoking and major depression, and are consistent with a causal effect on odds of decreased average total household income [odds ratio (OR) = 0. 966, 95% credible interval (CrI) = (0. 954, 0. 979)] and increased lifetime number of sexual partners [OR = 1. 023, 95% CrI = (1. 013, 1. 033)]. We also found evidence for a causal effect on ADHD for liability of arm predicted mass and weight [OR = 1. 452, 95% CrI = (1. 307, 1. 614) and OR = 1. 430, 95% CrI = (1. 326, 1. 539), respectively] and time spent watching television [OR = 1. 862, 95% CrI = (1. 545, 2. 246)], and evidence for a bidirectional effect for age of first sexual intercourse [beta = −0. 058, 95% CrI = (−0. 072, −0. 044) and OR = 0. 413, 95% CrI = (0. 372, 0. 457), respectively], odds of decreased age completed full-time education [OR = 0. 972, 95% CrI = (0. 962, 0. 981) and OR = 0. 435, 95% CrI = (0. 356, 0. 533), respectively] and years of schooling [beta = -0. 036, 95% CrI = (−0. 048, −0. 024) and OR = 0. 458, 95% CrI = (0. 411, 0. 511), respectively]. Our results may contribute to explain part of the widespread co-occurring traits and comorbid disorders across the lifespan of individuals with ADHD and may open new opportunities for developing preventive strategies for ADHD and for negative ADHD trajectories. |
| Ajuts: | Instituto de Salud Carlos III PI18/01788 Instituto de Salud Carlos III PI19/00721 Instituto de Salud Carlos III PI20/00041 Ministerio de Economía y Competitividad CD15/00199 Ministerio de Ciencia e Innovación CP09/00119 Ministerio de Economía y Competitividad CPII15/00023 |
| Drets: | Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original.  |
| Llengua: | Anglès |
| Document: | Article ; recerca ; Versió publicada |
| Matèria: | ADHD ; Mendelian randomization ; Causal analysis using summary effect estimates |
| Publicat a: | International journal of epidemiology, Vol. 52 (june 2022) , p. 386-402, ISSN 1464-3685 |
