"Acute kidney injury in critically ill patients with COVID-19 : The AKICOV multicenter study in Catalonia"
De La Vega, A. (Hospital Universitari Vall d'Hebron)
Navas Pérez, Ana Maria (Parc Taulí Hospital Universitari. Institut d'Investigació i Innovació Parc Taulí (I3PT))
Pérez-Carrasco, Marcos (Hospital Universitari Vall d'Hebron)
Sonet, María Torrens (Hospital de la Santa Creu i Sant Pau (Barcelona, Catalunya))
Buendia, Yolanda Diaz (Hospital del Mar (Barcelona, Catalunya))
Ballujera, Patricia Ortiz (Hospital Universitari de Girona Doctor Josep Trueta)
López, Miguel Rodríguez (Hospital de Sant Joan Despí Moisès Broggi)
Sabater-Riera, Joan (Hospital Universitari de Bellvitge)
Olmo-Isasmendi, Aitor (Hospital Universitari General de Catalunya)
Torra, Ester Vendrell (Hospital General de Granollers)
García-Pumarino, María Álvarez (Consorci Sanitari de Terrassa Barcelona)
Villamayor, Mercedes Ibarz (Hospital del Sagrat Cor (Barcelona, Catalunya))
Catalán Ibars, Rosa María (Hospital Universitari de Vic)
Zelaya, Iban Oliva (Hospital Universitari Joan XXIII de Tarragona)
Chica, Javier Pardos (Hospital Universitario Arnau de Vilanova de Lleida)
Anglès, Conxita Rovira (Hospital Universitari Sant Joan de Reus (Tarragona))
Tomasa-Irriguible, Teresa Maria (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol)
Serra, Anna Baró (Parc Hospitalari Martí i Julià)
Casanova, Edward J. (Hospital Asepeyo Sant Cugat del Vallès)
González de Molina, Francisco Javier (Hospital Universitari MútuaTerrassa (Terrassa, Catalunya))
Universitat Autònoma de Barcelona

Date:	2023
Abstract:	This study describes the incidence, evolution and prognosis of acute kidney injury (AKI) in critical COVID-19 during the first pandemic wave. We performed a prospective, observational, multicenter study of confirmed COVID-19 patients admitted to 19 intensive care units (ICUs) in Catalonia (Spain). Data regarding demographics, comorbidities, drug and medical treatment, physiological and laboratory results, AKI development, need for renal replacement therapy (RRT) and clinical outcomes were collected. Descriptive statistics and logistic regression analysis for AKI development and mortality were used. A total of 1,642 patients were enrolled (mean age 63 (15. 95) years, 67. 5% male). Mechanical ventilation (MV) was required for 80. 8% and 64. 4% of these patients, who were in prone position, while 67. 7% received vasopressors. AKI at ICU admission was 28. 4% and increased to 40. 1% during ICU stay. A total of 172 (10. 9%) patients required RRT, which represents 27. 8% of the patients who developed AKI. AKI was more frequent in severe acute respiratory distress syndrome (ARDS) ARDS patients (68% vs 53. 6%, p<0. 001) and in MV patients (91. 9% vs 77. 7%, p<0. 001), who required the prone position more frequently (74. 8 vs 61%, p<0. 001) and developed more infections. ICU and hospital mortality were increased in AKI patients (48. 2% vs 17. 7% and 51. 1% vs 19%, p <0. 001) respectively). AKI was an independent factor associated with mortality (IC 1. 587-3. 190). Mortality was higher in AKI patients who required RRT (55. 8% vs 48. 2%, p <0. 04). Conclusions There is a high incidence of AKI in critically ill patients with COVID-19 disease and it is associated with higher mortality, increased organ failure, nosocomial infections and prolonged ICU stay.
Rights:	Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original.
Language:	Anglès
Document:	Article ; recerca ; Versió publicada
Published in:	PloS one, Vol. 18 (april 2023) , ISSN 1932-6203

DOI: 10.1371/journal.pone.0284248
PMID: 37058544

13 p, 486.2 KB

The record appears in these collections:
Research literature > UAB research groups literature > Research Centres and Groups (research output) > Health sciences and biosciences > Institut d'Investigació en Ciencies de la Salut Germans Trias i Pujol (IGTP)
Research literature > UAB research groups literature > Research Centres and Groups (research output) > Health sciences and biosciences > Parc Taulí Research and Innovation Institute (I3PT
Articles > Research articles
Articles > Published articles