IL-1 Family Cytokines in Inflammatory Dermatoses : Pathogenetic Role and Potential Therapeutic Implications
Iznardo, Helena (Institut d'Investigació Biomèdica Sant Pau)
Puig Sanz, Lluís (Institut d'Investigació Biomèdica Sant Pau)
Universitat Autònoma de Barcelona

Date:	2022
Abstract:	The interleukin-1 (IL-1) family is involved in the correct functioning and regulation of the innate immune system, linking innate and adaptative immune responses. This complex family is composed by several cytokines, receptors, and co-receptors, all working in a balanced way to maintain homeostasis. Dysregulation of these processes results in tissue inflammation and is involved in the pathogenesis of common inflammatory dermatoses such as psoriasis, hidradenitis suppurativa, and atopic dermatitis. Therefore, therapeutic targeting of IL-1 pathways has been studied, and several monoclonal antibodies are currently being assessed in clinical trials. So far, promising results have been obtained with anti-IL-36R spesolimab and imsidolimab in pustular psoriasis, and their efficacy is being tested in other conditions.
Rights:	Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original.
Language:	Anglès
Document:	Article de revisió ; recerca ; Versió publicada
Subject:	Psoriasis ; Pustular psoriasis ; Hidradenitis suppurativa ; Atopic dermatitis ; Imsidolimab ; Spesolimab ; Bermekimab ; Etokimab ; IL-36 ; IL-36R ; IL-1 ; IL-33 ; Pathogenesis
Published in:	International journal of molecular sciences, Vol. 23 Núm. 16 (august 2022) , p. 9479, ISSN 1422-0067

DOI: 10.3390/ijms23169479
PMID: 36012744

17 p, 887.0 KB

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Research literature > UAB research groups literature > Research Centres and Groups (research output) > Health sciences and biosciences > Institut de Recerca Sant Pau
Articles > Research articles
Articles > Published articles