β-Synuclein as a candidate blood biomarker for synaptic degeneration in Alzheimer's disease
Mohaupt, Pablo (Université de Montpellier)
Pons, Marie-Laure (Université de Montpellier)
Vialaret, Jérôme (Université de Montpellier)
Delaby, Constance (Institut d'Investigació Biomèdica Sant Pau)
Hirtz, Christophe (Université de Montpellier)
Lehmann, Sylvain (Université de Montpellier)
Universitat Autònoma de Barcelona

Date:	2022
Abstract:	Synaptic degeneration is an early event closely associated with the course of Alzheimer's disease (AD). The identification of synaptic blood biomarkers is, therefore, of great interest and clinical relevance. The levels of most synaptic proteins are increased in the cerebrospinal fluid (CSF) of patients with AD, but their detection in blood is hitherto either unavailable or not very informative. This paradigm is related to their low concentration, their peripheral origin, or the presence of highly abundant blood proteins that hinder detection. In recent years, significant progress has been made in detecting the presynaptic protein β-synuclein. This mini-review summarizes the results that highlight the role of β-synuclein as a candidate blood marker for synaptic degeneration in AD.
Rights:	Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original.
Language:	Anglès
Document:	Article ; recerca ; Versió publicada
Subject:	Alzheimer's disease ; β-Synuclein ; Blood biomarker ; Synaptic dysfunction
Published in:	Alzheimer's research & therapy, Vol. 14 (november 2022) , ISSN 1758-9193

DOI: 10.1186/s13195-022-01125-1
PMID: 36451155

4 p, 880.7 KB

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Research literature > UAB research groups literature > Research Centres and Groups (research output) > Health sciences and biosciences > Institut de Recerca Sant Pau
Articles > Research articles
Articles > Published articles