Outcomes of COVID-19 Infection in People Previously Vaccinated Against Influenza : Population-Based Cohort Study Using Primary Health Care Electronic Records
Giner-Soriano, Maria ![Identificador ORCID](/img/uab/orcid.ico)
(Institut Universitari d'Investigació en Atenció Primària Jordi Gol)
de Dios, Vanessa ![Identificador ORCID](/img/uab/orcid.ico)
(Hospital Clínic i Provincial de Barcelona)
Ouchi, Dan ![Identificador ORCID](/img/uab/orcid.ico)
(Institut Universitari d'Investigació en Atenció Primària Jordi Gol)
Vilaplana-Carnerero, Carles ![Identificador ORCID](/img/uab/orcid.ico)
(Institut Universitari d'Investigació en Atenció Primària Jordi Gol)
Monteagudo, Mònica ![Identificador ORCID](/img/uab/orcid.ico)
(Institut Universitari d'Investigació en Atenció Primària Jordi Gol)
Morros, Rosa ![Identificador ORCID](/img/uab/orcid.ico)
(Institut Universitari d'Investigació en Atenció Primària Jordi Gol)
Universitat Autònoma de Barcelona
Fecha: |
2022 |
Resumen: |
A possible link between influenza immunization and susceptibility to the complications of COVID-19 infection has been previously suggested owing to a boost in the immunity against SARS-CoV-2. This study aimed to investigate whether individuals with COVID-19 could have benefited from vaccination against influenza. We hypothesized that the immunity resulting from the previous influenza vaccination would boost part of the immunity against SARS-CoV-2. We performed a population-based cohort study including all patients with COVID-19 with registered entries in the primary health care (PHC) electronic records during the first wave of the COVID-19 pandemic (March 1 to June 30, 2020) in Catalonia, Spain. We compared individuals who took an influenza vaccine before being infected with COVID-19, with those who had not taken one. Data were obtained from Information System for Research in Primary Care, capturing PHC information of 5. 8 million people from Catalonia. The main outcomes assessed during follow-up were a diagnosis of pneumonia, hospital admission, and mortality. We included 309,039 individuals with COVID-19 and compared them on the basis of their influenza immunization status, with 114,181 (36. 9%) having been vaccinated at least once and 194,858 (63. 1%) having never been vaccinated. In total, 21,721 (19%) vaccinated individuals and 11,000 (5. 7%) unvaccinated individuals had at least one of their outcomes assessed. Those vaccinated against influenza at any time (odds ratio [OR] 1. 14, 95% CI 1. 10-1. 19), recently (OR 1. 13, 95% CI 1. 10-1. 18), or recurrently (OR 1. 10, 95% CI 1. 05-1. 15) before being infected with COVID-19 had a higher risk of presenting at least one of the outcomes than did unvaccinated individuals. When we excluded people living in long-term care facilities, the results were similar. We could not establish a protective role of the immunity conferred by the influenza vaccine on the outcomes of COVID-19 infection, as the risk of COVID-19 complications was higher in vaccinated than in unvaccinated individuals. Our results correspond to the first wave of the COVID-19 pandemic, where more complications and mortalities due to COVID-19 had occurred. Despite that, our study adds more evidence for the analysis of a possible link between the quality of immunity and COVID-19 outcomes, particularly in the PHC setting. |
Derechos: |
Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original. ![Creative Commons](/img/licenses/by.ico) |
Lengua: |
Anglès |
Documento: |
Article ; recerca ; Versió publicada |
Materia: |
Cohort study ;
COVID-19 ;
Eheatlh ;
Electronic health records ;
Epidemiology ;
Health outcome ;
Influenza vaccines ;
Mortality ;
Pneumonia ;
Primary health care ;
Public health ;
SARS-CoV-2 ;
Vaccination |
Publicado en: |
JMIR Public Health and Surveillance, Vol. 8 (november 2022) , ISSN 2369-2960 |
DOI: 10.2196/36712
PMID: 36265160
PMID: 36
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Registro creado el 2023-09-15, última modificación el 2023-09-18