Intraoperative irradiation in breast cancer : preliminary results in 80 patients as partial breast irradiation or anticipated boost prior to hypo-fractionated whole breast irradiation
Li, X. (Universitat Autònoma de Barcelona)
Sanz, Javier (Hospital del Mar (Barcelona, Catalunya))
Argudo, Núria (Hospital del Mar (Barcelona, Catalunya))
Vernet-Tomas, Maria (Hospital del Mar (Barcelona, Catalunya))
Rodríguez, N. (Hospital del Mar (Barcelona, Catalunya))
Torrent, L. (Hospital del Mar (Barcelona, Catalunya))
Fernández-Velilla, E. (Hospital del Mar (Barcelona, Catalunya))
Pera, O. (Hospital del Mar (Barcelona, Catalunya))
Huang, Y. (Universitat Autònoma de Barcelona)
Nicolau, P. (Hospital del Mar (Barcelona, Catalunya))
Jiménez Gómez, Marta (Hospital del Mar (Barcelona, Catalunya))
Segura, M. (Hospital del Mar (Barcelona, Catalunya))
Algara, Manuel (Hospital del Mar (Barcelona, Catalunya))

Data:	2021
Resum:	To present the first results of intraoperative irradiation (IORT) in breast cancer with a low-energy photon system used as partial breast irradiation (PBI) or as an anticipated boost before whole breast hypo-fractionated irradiation (IORT + WBI), concerning tolerance, side effects, quality of life, and patient-reported outcomes. Eighty patients treated with an Intrabeam ® system of 50 kV X-rays received a 20 Gy dose intraoperatively were included. Moderate daily hypofractionation of 2. 7 Gy in 15 fractions up to 40. 5 Gy was administered if high-risk factors were present. Acute post-operative toxicity, surgery complications, chronic toxicity, patient-reported cosmesis and Breast-Q questionnaire were performed at follow-up visits. Thirty-one patients were treated as PBI and the remaining 49 as IORT + WBI. Only the IORT + WBI group presented acute toxicity, mainly mild acute dermatitis (11 patients) and one subacute mastitis. A total of 20 patients presented fibrosis (18 patients grade I, 2 patients grade II), 15 (30. 5%) patients in the IORT + WBI group and 3 (9. 6%) patients in the group of PBI. The cosmesis evaluation in 73 patients resulted poor, fair, good or excellent in 2, 7, 38 and 26 patients, respectively. In PBI group Breast-Q scored higher, especially in terms of their psychosocial well-being (78 vs 65) and satisfaction with radiation-induced toxicity (77 vs 72, respectively) compared to IORT + WBI group. IORT is a well-tolerated procedure with low toxicity, good cosmesis and favorable patient-reported outcomes mainly when administered as PBI.
Drets:	Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original.
Llengua:	Anglès
Document:	Article ; recerca ; Versió publicada
Matèria:	Boost ; Breast cancer ; Hypofractionation ; Intraoperative irradiation ; Partial breast irradiation ; Patient reported outcomes
Publicat a:	Clinical & translational oncology, Vol. 24 (november 2021) , p. 829-835, ISSN 1699-3055

DOI: 10.1007/s12094-021-02728-0
PMID: 34792725

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