Electrophysiological effects of adipose graft transposition procedure (AGTP) on the post-myocardial infarction scar : A multimodal characterization of arrhythmogenic substrate
Adeliño, Raquel (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol)
Martínez-Falguera, Daina (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol)
Curiel, Carolina (Boston Scientific Department. Barcelona Delegation)
Teis, Albert (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol)
Marsal, Roger (Boston Scientific Department. Barcelona Delegation)
Rodríguez-Leor, Oriol (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol)
Prat-Vidal, Cristina (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol)
Fadeuilhe, Edgar (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol)
Aranyó, Júlia (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol)
Revuelta-López, Elena (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol)
Sarrias, Axel (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol)
Bazán, Víctor (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol)
Andrés-Cordón, Joan Francesc (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol)
Roura, Santiago (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol)
Villuendas-Sabaté, Roger (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol)
Lupón, Josep (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol)
Bayés-Genís, Antoni (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol)
Gálvez-Montón, Carolina (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol)
Bisbal, Felipe (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol)
Universitat Autònoma de Barcelona

Date:	2022
Abstract:	To assess the arrhythmic safety profile of the adipose graft transposition procedure (AGTP) and its electrophysiological effects on post-myocardial infarction (MI) scar. Myocardial repair is a promising treatment for patients with MI. The AGTP is a cardiac reparative therapy that reduces infarct size and improves cardiac function. The impact of AGTP on arrhythmogenesis has not been addressed. MI was induced in 20 swine. Contrast-enhanced magnetic resonance (ce-MRI), electrophysiological study (EPS), and left-ventricular endocardial high-density mapping were performed 15 days post-MI. Animals were randomized 1:1 to AGTP or sham-surgery group and monitored with ECG-Holter. Repeat EPS, endocardial mapping, and ce-MRI were performed 30 days post-intervention. Myocardial SERCA2, Connexin-43 (Cx43), Ryanodine receptor-2 (RyR2), and cardiac troponin-I (cTnI) gene and protein expression were evaluated. The AGTP group showed a significant reduction of the total infarct scar, border zone and dense scar mass by ce-MRI (p = 0. 04), and a decreased total scar and border zone area in bipolar voltage mapping (p < 0. 001). AGTP treatment significantly reduced the area of very-slow conduction velocity (<0. 2 m/s) (p = 0. 002), the number of deceleration zones (p = 0. 029), and the area of fractionated electrograms (p = 0. 005). No differences were detected in number of induced or spontaneous ventricular arrhythmias at EPS and Holter-monitoring. SERCA2, Cx43, and RyR2 gene expression were decreased in the infarct core of AGTP-treated animals (p = 0. 021, p = 0. 018, p = 0. 051, respectively). AGTP is a safe reparative therapy in terms of arrhythmic risk and provides additional protective effect against adverse electrophysiological remodeling in ischemic heart disease.
Rights:	Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original.
Language:	Anglès
Document:	Article ; recerca ; Versió publicada
Subject:	Adipose graft transposition procedure ; Arrhythmic risk ; Mapping ; Myocardial infarction ; Myocardial repair ; Ventricular tachycardia
Published in:	Frontiers in Cardiovascular Medicine, Vol. 9 (september 2022) , ISSN 2297-055X

DOI: 10.3389/fcvm.2022.983001
PMID: 36204562

13 p, 3.5 MB

The record appears in these collections:
Research literature > UAB research groups literature > Research Centres and Groups (research output) > Health sciences and biosciences > Institut d'Investigació en Ciencies de la Salut Germans Trias i Pujol (IGTP)
Articles > Research articles
Articles > Published articles