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| Pàgina inicial > Articles > Articles publicats > Functional brain connectivity prior to the COVID-19 outbreak moderates the effects of coping and perceived stress on mental health changes. A first year of COVID-19 pandemic follow-up study |
(Institut Germans Trias i Pujol. Institut Guttmann) (Institut de Recerca Biomèdica August Pi i Sunyer (IDIBAPS), Barcelona, Spain) (Institut Germans Trias i Pujol) (Institut Germans Trias i Pujol) (Universitat de Barcelona) (Institut de Recerca Biomèdica August Pi i Sunyer (IDIBAPS), Barcelona, Spain) (Institut Germans Trias i Pujol. Institut Guttmann) (Hospital Clínic i Provincial de Barcelona) (Hospital Clínic i Provincial de Barcelona) (Institut Germans Trias i Pujol) (Department of Neurology, Harvard Medical School, Boston, MA, USA) (Institut Germans Trias i Pujol. Institut Guttmann)
| Data: | 2022 |
| Resum: | The COVID-19 pandemic provides a unique opportunity to investigate the psychological impact of a global major adverse situation. Our aim was to study, in a longitudinal prospective, the demographic, psychological and neurobiological factors associated with inter-individual differences in resilience to mental health pandemic impact. We included 2,023 healthy participants (age: 54. 32±7. 18 years, 65. 69% females) from the Barcelona Brain Health Initiative cohort. A linear mixed model was used to characterize the change in anxiety and depression symptoms based on the collected pre- and during-COVID-19 data. During pandemic, psychological variables assessing individual differences in perceived stress and coping strategies were obtained. Additionally, in a subsample (N=433, age:53. 02 ± 7. 04 years, 46. 88% females) with pre-pandemic resting-state functional magnetic resonance imaging available, networks' system segregation (SyS) was calculated. Multivariate linear models were fitted to test associations between COVID-19-related changes in mental health and demographics, psychological features and brain networks status. The whole sample showed a general increase in anxiety and depressive symptoms after the pandemic onset, and both age and sex were independent predictors. Coping strategies attenuated the impact of perceived stress on mental health. SyS of fronto-parietal control and default mode networks were found to modulate the impact of perceived stress on mental health. Preventive strategies destined for the promotion of mental health at an individual's level during future similar adverse events should consider intervening on sociodemographic and psychological factors, as well as their interplay with neurobiological substrates. |
| Ajuts: | Agencia Estatal de Investigación RTI2018-095181-B-C21 Agencia Estatal de Investigación CEX2018-000806-S Agència de Gestió d'Ajuts Universitaris i de Recerca 2018PROD00172 Agència de Gestió d'Ajuts Universitaris i de Recerca 2017SGR748 |
| Drets: | Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, i la comunicació pública de l'obra, sempre que no sigui amb finalitats comercials, i sempre que es reconegui l'autoria de l'obra original. No es permet la creació d'obres derivades.  |
| Llengua: | Anglès |
| Document: | Article ; recerca ; Versió publicada |
| Matèria: | Mental health ; Coping strategies ; Perceived stress ; Brain networks ; COVID-19 pandemic |
| Publicat a: | Biological Psychiatry. Cognitive Neuroscience and Neuroimaging, august 2022, ISSN 2451-9030 |
