Peripheral Neutrophil-to-Lymphocyte Ratio in Bronchiectasis : A Marker of Disease Severity
Martinez-García, Miguel Ángel (Centro de Investigación Biomédica en Red de Enfermedades Respiratorias)
Olveira, Casilda (Instituto de Investigación Biomédica de Málaga (IBIMA). Complejo Hospitalario Carlos Haya. Universidad de Málaga. Servicio de Neumología)
Girón, Rosa (Instituto de Investigación Hospital Universitario de la Princesa. Servicio de Neumología)
García Clemente, Marta (Instituto de Investigación Sanitaria del Principado de Asturias. Servicio de Neumología)
Máiz-Carro, Luis (Hospital Ramón y Cajal. Servicio de Neumología)
Sibila, Oriol (Institut d'Investigacions Biomèdiques August Pi i Sunyer)
Golpe, Rafael (Hospital Universitario Lucus Augusti (Lugo). Servicio de Neumología)
Méndez, Raúl (Centro de Investigación Biomédica en Red de Enfermedades Respiratorias)
Rodriguez Hermosa, Juan Luis (Instituto de Investigación Sanitaria del Hospital Clínico San Carlos)
Barreiro, Esther (Institut Municipal d'Investigació Mèdica (Barcelona, Catalunya))
Prados, Concepción (Hospital Universitario La Paz (Madrid))
Rodríguez López, Juan (Hospital Universitario San Agustín (Avilés))
de la Rosa Carrillo, David (Institut d'Investigació Biomèdica Sant Pau)

Data:	2022
Resum:	Most patients with bronchiectasis have a predominantly neutrophilic inflammatory profile, although other cells such as lymphocytes (as controllers of bronchial inflammation) and eosinophils also play a significant pathophysiological role. Easy-to-interpret blood biomarkers with a discriminative capacity for severity or prognosis are needed. The objective of this study was to assess whether the peripheral neutrophil-to-lymphocyte ratio (NLR) is associated with different outcomes of severity in bronchiectasis. A total of 1369 patients with bronchiectasis from the Spanish Registry of Bronchiectasis were included. To compare groups, the sample was divided into increasing quartiles of NLR ratio. Correlations between quantitative variables were established using Pearson's P test. A simple linear regression (with the value of exacerbations as a quantitative variable) was used to determine the independent relationship between the number and severity of exacerbations and the NLR ratio. The area under the curve (AUC)-ROC was used to determine the predictive capacity of the NLR for severe bronchiectasis, according to the different multidimensional scores. Mean age: 69 (15) years (66. 3% of women). The mean NLR was 2. 92 (2. 03). A higher NLR was associated with more severe bronchiectasis (with an especially significant discriminative power for severe forms) according to the commonly used scores (FACED, E-FACED and BSI), as well as with poorer quality of life (SGRQ), more comorbidities (Charlson index), infection by pathogenic microorganisms, and greater application of treatment. Furthermore, the NLR correlated better with severity scores than other parameters of systemic inflammation. Finally, it was an independent predictor of the incident number and severity of exacerbations. In conclusion, the NLR is an inexpensive and easy-to-measure marker of systemic inflammation for determining severity and predicting exacerbations (especially the most severe) in patients with bronchiectasis.
Ajuts:	Instituto de Salud Carlos III JR21/00051
Nota:	Altres ajuts: CIBER-Consorcio Centro de Investigación Biomédica en Red (CIBERES); Ministerio de Ciencia e Innovación; European Union's, European Regional Development Fund.
Drets:	Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original.
Llengua:	Anglès
Document:	Article ; recerca ; Versió publicada
Matèria:	Neutrophil ; Lymphocyte ; Bronchiectasis ; Severity ; Exacerbations
Publicat a:	Biomolecules, Vol. 12 Núm. 10 (october 2022) , p. 1399, ISSN 2218-273X

DOI: 10.3390/biom12101399
PMID: 36291608

13 p, 750.8 KB

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