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Pàgina inicial > Articles > Articles publicats > MDA-LDL vaccination induces athero-protective germinal-center-derived antibody responses |
Data: | 2022 |
Resum: | Atherosclerosis is a chronic inflammatory disease of the arteries that can lead to thrombosis, infarction, and stroke and is the leading cause of mortality worldwide. Immunization of pro-atherogenic mice with malondialdehyde-modified low-density lipoprotein (MDA-LDL) neo-antigen is athero-protective. However, the immune response to MDA-LDL and the mechanisms responsible for this athero-protection are not completely understood. Here, we find that immunization of mice with MDA-LDL elicits memory B cells, plasma cells, and switched anti-MDA-LDL antibodies as well as clonal expansion and affinity maturation, indicating that MDA-LDL triggers a bona fide germinal center antibody response. Further, Prdm1 Aicda-Cre Ldlr pro-atherogenic chimeras, which lack germinal center-derived plasma cells, show accelerated atherosclerosis. Finally, we show that MDA-LDL immunization is not athero-protective in mice lacking germinal-center-derived plasma cells. Our findings give further support to the development of MDA-LDL-based vaccines for the prevention or treatment of atherosclerosis. |
Ajuts: | Ministerio de Economía y Competitividad SVP-2014-068216 Ministerio de Economía y Competitividad SVP-2014-068289 Ministerio de Economía y Competitividad HR17-00247 Ministerio de Economía y Competitividad SVP-2014-068216 Ministerio de Economía y Competitividad SVP-2014-068289 Agencia Estatal de Investigación PID2019-106773RB-I00/AEI/10.13039/501100011033 Agencia Estatal de Investigación CEX2020-001041-S |
Drets: | Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, i la comunicació pública de l'obra, sempre que no sigui amb finalitats comercials, i sempre que es reconegui l'autoria de l'obra original. No es permet la creació d'obres derivades. |
Llengua: | Anglès |
Document: | Article ; recerca ; Versió publicada |
Matèria: | Enteral nutrition ; Immunonutrition ; Intensive care unit ; Protein delivery ; Outcomes ; Inflammatory response |
Publicat a: | Cell reports, Vol. 41 Núm. 2 (november 2022) , p. 111468, ISSN 2211-1247 |
19 p, 4.3 MB |