Development and Validation of a Tool to Assess the Quality of Clinical Practice Guideline Recommendations
Brouwers, M.C. (University of Ottawa)
Spithoff, K. (McMaster University (Canadà))
Kerkvliet, K. (McMaster University (Canadà))
Alonso-Coello, Pablo (Institut d'Investigació Biomèdica Sant Pau)
Burgers, J. (Dutch College of General Practitioners)
Cluzeau, F. (St Mary's Hospital)
Férvers, B. (Centre León Bérard)
Graham, I. (University of Ottawa)
Grimshaw, J. (University of Ottawa)
Hanna, S. (McMaster University. Hamilton)
Kastner, M. (North York General Hospital)
Kho, M. (McMaster University (Canadà))
Qaseem, Amir (American College of Physicians)
Straus, S. (Li Ka Shing Knowledge Institute of St. Michael's Hospital)
Florez, Ivan D (University of Antioquia)
Universitat Autònoma de Barcelona

Date:	2020
Abstract:	Clinical practice guidelines (CPGs) may lack rigor and suitability to the setting in which they are to be applied. Methods to yield clinical practice guideline recommendations that are credible and implementable remain to be determined. To describe the development of AGREE-REX (Appraisal of Guidelines Research and Evaluation-Recommendations Excellence), a tool designed to evaluate the quality of clinical practice guideline recommendations. A cross-sectional study of 322 international stakeholders representing CPG developers, users, and researchers was conducted between December 2015 and March 2019. Advertisements to participate were distributed through professional organizations as well as through the AGREE Enterprise social media accounts and their registered users. Between 2015 and 2017, participants appraised 1 of 161 CPGs using the Draft AGREE-REX tool and completed the AGREE-REX Usability Survey. Usability and measurement properties of the tool were assessed with 7-point scales (1 indicating strong disagreement and 7 indicating strong agreement). Internal consistency of items was assessed with the Cronbach, and the Spearman-Brown reliability adjustment was used to calculate reliability for 2 to 5 raters. A total of 322 participants (202 female participants [62. 7%]; 83 aged 40-49 years [25. 8%]) rated the survey items (on a 7-point scale). All 11 items were rated as easy to understand (with a mean [SD] ranging from 5. 2 [1. 38] for the alignment of values item to 6. 3 [0. 87] for the evidence item) and easy to apply (with a mean [SD] ranging from 4. 8 [1. 49] for the alignment of values item to 6. 1 [1. 07] for the evidence item). Participants provided favorable feedback on the tool's instructions, which were considered clear (mean [SD], 5. 8 [1. 06]), helpful (mean [SD], 5. 9 [1. 00]), and complete (mean [SD], 5. 8 [1. 11]). Participants considered the tool easy to use (mean [SD], 5. 4 [1. 32]) and thought that it added value to the guideline enterprise (mean [SD], 5. 9 [1. 13]). Internal consistency of the items was high (Cronbach = 0. 94). Positive correlations were found between the overall AGREE-REX score and the implementability score (r = 0. 81) and the clinical credibility score (r = 0. 76). This cross-sectional study found that the AGREE-REX tool can be useful in evaluating CPG recommendations, differentiating among them, and identifying those that are clinically credible and implementable for practicing health professionals and decision makers who use recommendations to inform clinical policy. .
Rights:	Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original.
Language:	Anglès
Document:	Article ; recerca ; Versió publicada
Published in:	JAMA network open, Vol. 3 Núm. 5 (27 2020) , p. 5535, ISSN 2574-3805

DOI: 10.1001/jamanetworkopen.2020.5535
PMID: 32459354

13 p, 851.6 KB

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Research literature > UAB research groups literature > Research Centres and Groups (research output) > Health sciences and biosciences > Institut de Recerca Sant Pau
Articles > Research articles
Articles > Published articles