Clinical and radiological characteristics and outcome of wake-up intracerebral hemorrhage
Martí-Fàbregas, Joan (Institut d'Investigació Biomèdica Sant Pau)
Delgado Mederos, Raquel (Institut d'Investigació Biomèdica Sant Pau)
Martínez-Domeño, Alejandro (Institut d'Investigació Biomèdica Sant Pau)
Camps-Renom, Pol (Institut d'Investigació Biomèdica Sant Pau)
Guisado-Alonso, Daniel (Institut d'Investigació Biomèdica Sant Pau)
Guasch-Jiménez, Marina (Hospital de la Santa Creu i Sant Pau (Barcelona, Catalunya))
Marrero-González, Paula (Hospital de la Santa Creu i Sant Pau (Barcelona, Catalunya))
Jiménez-Xarrié, Elena (Institut d'Investigació Biomèdica Sant Pau)
Marín, Rebeca (Institut d'Investigació Biomèdica Sant Pau)
Prats-Sánchez, Luis Antonio (Institut d'Investigació Biomèdica Sant Pau)
Universitat Autònoma de Barcelona

Date:	2020
Abstract:	There is little information on the characteristics of patients with wake-up intracerebral hemorrhage (WU-ICH). We aimed to evaluate frequency and relevant differences between WU-ICH and while-awake (WA) ICH patients. This is a retrospective study of a prospective database of consecutive patients with spontaneous ICH, who were classified as WU-ICH, WA-ICH or UO-ICH (unclear onset). We collected demographic, clinical and radiological data, prognostic and therapeutic variables, and outcome [(neurological deterioration, mortality, functional outcome (favorable when modified Rankin scale score 0-2)]. From a total of 466 patients, 98 (25. 8%) were classified as UO-ICH according to the type of onset and therefore excluded. We studied 368 patients (mean age 73. 9 ± 13. 8, 51. 4% men), and compared 95 (25. 8%) WU-ICH with 273 (74. 2%) WA-ICH. Patients from the WU-ICH group were significantly older than WA-ICH (76. 9 ± 14. 3 vs 72. 8 ± 13. 6, p = 0. 01) but the vascular risk factors were similar. Compared to the WA-ICH group, patients from the WU-ICH group had a lower GCS score or a higher NIHSS score and a higher ICH score, and were less often admitted to a stroke unit or intensive care unit. There were no differences between groups in location, volume, rate of hematoma growth, frequency of intraventricular hemorrhage and outcome. One in five patients with spontaneous ICH are WU-ICH patients. Other than age, there are no relevant differences between WU and WA groups. Although WU-ICH is associated with worse prognostic markers vital and functional outcome is similar to WA-ICH patients.
Grants:	Ministerio de Sanidad y Consumo RD06/0019/0010
Rights:	Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original.
Language:	Anglès
Document:	Article ; recerca ; Versió publicada
Subject:	Diseases of the nervous system ; Medical research ; Neurological disorders ; Stroke
Published in:	Scientific reports, Vol. 10 Núm. 1 (january 2020) , p. 18749, ISSN 2045-2322

DOI: 10.1038/s41598-020-75750-x
PMID: 33127937

7 p, 858.2 KB

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Research literature > UAB research groups literature > Research Centres and Groups (research output) > Health sciences and biosciences > Institut de Recerca Sant Pau
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