Intravenous Statin Administration During Myocardial Infarction Compared With Oral Post-Infarct Administration
Mendieta, G. (Clinic Hospital)
Ben-Aicha Gonzalez, Soumaya (Hospital de la Santa Creu i Sant Pau (Barcelona, Catalunya))
Gutiérrez, M. (Hospital de la Santa Creu i Sant Pau (Barcelona, Catalunya))
Casaní, Laura (Hospital de la Santa Creu i Sant Pau (Barcelona, Catalunya))
Aržanauskaitė, M. (Hospital de la Santa Creu i Sant Pau (Barcelona, Catalunya))
Carreras, F. (Hospital de la Santa Creu i Sant Pau (Barcelona, Catalunya))
Sabate, M. (Clinic Hospital)
Badimon, Lina (Institut d'Investigació Biomèdica Sant Pau)
Vilahur, Gemma (Institut d'Investigació Biomèdica Sant Pau)
Universitat Autònoma de Barcelona

Date:	2020
Abstract:	Beyond lipid-lowering, statins exert cardioprotective effects. High-dose statin treatment seems to reduce cardiovascular complications in high-risk patients. The ideal timing and administration regime remain unknown. This study compared the cardioprotective effects of intravenous statin administration during myocardial infarction (MI) with oral administration immediately post-MI. Hypercholesterolemic pigs underwent MI induction (90 min of ischemia) and were kept for 42 days. Animals were distributed in 3 arms (A): A1 received an intravenous bolus of atorvastatin during MI; A2 received an intravenous bolus of vehicle during MI; and A3 received oral atorvastatin within 2 h post-MI. A1 and A3 remained on daily oral atorvastatin for the following 42 days. Cardiac magnetic resonance analysis (days 3 and 42 post-MI) and molecular/histological studies were performed. At day 3, A1 showed a 10% reduction in infarct size compared with A3 and A2 and a 50% increase in myocardial salvage. At day 42, both A1 and A3 showed a significant decrease in scar size versus A2; however, A1 showed a further 24% reduction versus A3. Functional analyses revealed improved systolic performance in A1 compared with A2 and less wall motion abnormalities in the jeopardized myocardium versus both groups at day 42. A1 showed enhanced collagen content and AMP-activated protein kinase activation in the scar, increased vessel density in the penumbra, higher tumor necrosis factor α plasma levels and lower peripheral blood mononuclear cell activation versus both groups. Intravenous administration of atorvastatin during MI limits cardiac damage, improves cardiac function, and mitigates remodeling to a larger extent than when administered orally shortly after reperfusion. This therapeutic approach deserves to be investigated in ST-segment elevation MI patients.
Rights:	Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, i la comunicació pública de l'obra, sempre que no sigui amb finalitats comercials, i sempre que es reconegui l'autoria de l'obra original. No es permet la creació d'obres derivades.
Language:	Anglès
Document:	Article ; recerca ; Versió publicada
Subject:	Cardioprotection ; Myocardial infarction ; Pigs ; Statin ; Timing
Published in:	Journal of the American College of Cardiology, Vol. 75 Núm. 12 (31 2020) , p. 1386-1402, ISSN 1558-3597

DOI: 10.1016/j.jacc.2020.01.042
PMID: 32216907

17 p, 3.0 MB

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Research literature > UAB research groups literature > Research Centres and Groups (research output) > Health sciences and biosciences > Institut de Recerca Sant Pau
Articles > Research articles
Articles > Published articles