Semaphorin-3F/Neuropilin-2 Transcriptional Expression as a Predictive Biomarker of Occult Lymph Node Metastases in HNSCC
Meler-Claramonte, Carla (Institut d'Investigació Sanitària Pere Virgili)
Avilés-Jurado, Francesc Xavier (Agència de Gestió d'Ajuts Universitaris i de Recerca)
Vilaseca, Isabel (Universitat de Barcelona. Departament de Cirurgia i Especialitats Medicoquirúrgiques)
Terra, Ximena (Universitat Rovira i Virgili. Departament de Bioquímica i Biotecnologia)
Bragado, Paloma (Universidad Complutense de Madrid. Departamento de Bioquímica y Biología Molecular)
Fuster, Gemma (Universitat de Barcelona. Universitat de Barcelona. Departament de Bioquímica i Biomedicina Molecular)
León i Vintró, Xavier (Institut d'Investigació Biomèdica Sant Pau)
Camacho, Mercedes (Institut d'Investigació Biomèdica Sant Pau)
Universitat Autònoma de Barcelona

Date:	2022
Abstract:	The expression of the semaphorin-3F (SEMA3F) and neuropilin-2 (NRP2) is involved in the regulation of lymphangiogenesis. The present study analyzes the relationship between the transcriptional expression of the SEMA3F-NRP2 genes and the presence of occult lymph node metastases in patients with cN0 head and neck squamous cell carcinomas. We analyzed the transcriptional expression of SEMA3F and NRP2 in a cohort of 53 patients with cN0 squamous cell carcinoma treated with an elective neck dissection. Occult lymph node metastases were found in 37. 7% of the patients. Patients with occult lymph node metastases (cN0/pN+) had significantly lower SEMA3F expression values than patients without lymph node involvement (cN0/pN0). Considering the expression of the SEMA3F-NRP2 genes, patients were classified into two groups according to the risk of occult nodal metastasis: Group 1 (n = 34), high SEMA3F/low NRP2 expression, with a low risk of occult nodal involvement (14. 7% cN0/pN+); Group 2 (n = 19), low SEMA3F or high SEMA3F/high NRP2 expression, with a high risk of occult nodal involvement (78. 9% cN0/pN+). Multivariate analysis showed that patients in Group 2 had a 26. 2 higher risk of lymph node involvement than patients in Group 1. There was a significant relationship between the transcriptional expression values of the SEMA3F-NRP2 genes and the risk of occult nodal metastases.
Grants:	Instituto de Salud Carlos III FIS PI15/02047 Instituto de Salud Carlos III FIS PI18/0844 Instituto de Salud Carlos III FIS PI19/01661 Ministerio de Economía y Competitividad PID2019-104991RB-I00
Note:	Altres ajuts: Fondo Europeo de Desarrollo Regional (FEDER), A Way to Build Europe; Asociación Española contra el Cáncer (LABAE18025AVIL).
Rights:	Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original.
Language:	Anglès
Document:	Article ; recerca ; Versió publicada
Subject:	Semaphorin-3F ; Neuropilin-2 ; Occult lymph node metastases ; Elective neck dissection ; Head and neck squamous cell carcinoma ; HNSCC ; Lymphangiogenesis
Published in:	Cancers, Vol. 14, Núm. 9 (May 2022) , art. 2259, ISSN 2072-6694

DOI: 10.3390/cancers14092259
PMID: 35565388

12 p, 670.8 KB

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Articles > Research articles
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