Feline Injection-Site Sarcoma and Other Adverse Reactions to Vaccination in Cats
Hartmann, Katrin (Centre for Clinical Veterinary Medicine)
Egberink, Herman (University of Utrecht. Department of Biomolecular Health Sciences)
Möstl, Karin (University of Veterinary Medicine. Department for Pathobiology)
Addie, Diane D (Maison Zabal)
Belák, Sándor (Swedish University of Agricultural Sciences. Department of Biomedical Sciences and Veterinary Public Health (BVF))
Boucraut-Baralon, Corine (Scanelis Veterinary Test Laboratory)
Frymus, Tadeusz (Warsaw University of Life Sciences-SGGW. Department of Small Animal Diseases with Clinic)
Lloret, Albert (Universitat Autònoma de Barcelona. Hospital Clínic Veterinari)
Hofmann-Lehmann, Regina (University of Zuich. Department of Clinical Diagnostics and Services)
Marsilio, Fulvio (Università degli Studi di Teramo. Faculty of Veterinary Medicine)
Pennisi, Maria Grazia (Università di Messina. Dipartimento di Scienze Veterinarie)
Tasker, Séverine (Linnaeus Veterinary)
Thiry, Etienne (Liège University. Department of Infectious and Parasitic Diseases)
Truyen, Uwe (University of Leipzig. Institute of Animal Hygiene and Veterinary Public Health)
Hosie, Margaret J (University of Glasgow Centre for Virus Research)

Data:	2023
Resum:	Vaccine-associated adverse events (VAAEs), including feline injection-site sarcomas (FISSs), occur only rarely but can be severe. Understanding potential VAAEs is an important part of informed owner consent for vaccination. In this review, the European Advisory Board on Cat Diseases (ABCD), a scientifically independent board of feline medicine experts, presents the current knowledge on VAAEs in cats, summarizing the literature and filling the gaps where scientific studies are missing with expert opinion to assist veterinarians in adopting the best vaccination practice. VAAEs are caused by an aberrant innate or adaptive immune reaction, excessive local reactions at the inoculation site, an error in administration, or failure in the manufacturing process. FISS, the most severe VAAE, can develop after vaccinations or injection of other substances. Although the most widely accepted hypothesis is that chronic inflammation triggers malignant transformation, the pathogenesis of FISS is not yet fully understood. No injectable vaccine is risk-free, and therefore, vaccination should be performed as often as necessary, but as infrequently as possible. Vaccines should be brought to room temperature prior to administration and injected at sites in which FISS surgery would likely be curative; the interscapular region should be avoided. Post-vaccinal monitoring is essential.
Drets:	Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original.
Llengua:	Anglès
Document:	Article ; recerca ; Versió publicada
Matèria:	VAAE ; FISS ; Side effect ; Adverse event ; Vaccine ; Immunization ; Hypersensitivity reaction ; Anaphylaxis
Publicat a:	Viruses, Vol. 15 (august 2023) , ISSN 1999-4915

DOI: 10.3390/v15081708
PMID: 37632050

20 p, 1.0 MB

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