Altered brain metabolome is associated with memory impairment in the rTG4510 mouse model of tauopathy
Tondo Colomer, Mireia (Institut d'Investigació Biomèdica Sant Pau)
Wasek, Brandi (Baylor Scott & White Research Institute)
Escolà-Gil, Joan Carles (Institut d'Investigació Biomèdica Sant Pau)
Gonzalo Calvo, David de (Institut d'Investigació Biomèdica Sant Pau)
Harmon, Clinton (Baylor Scott & White Research Institute)
Arning, Erland (Baylor Scott & White Research Institute)
Bottiglieri, Teodoro (Baylor Scott & White Research Institute)
Universitat Autònoma de Barcelona

Date:	2020
Abstract:	Alzheimer's disease (AD) is characterized, amongst other features, by the pathologic accumulation of abnormally phosphorylated tau filaments in neurons that lead to neurofibrillary tangles. However, the molecular mechanisms by which the abnormal processing of tau leads to neurodegeneration and cognitive impairment remain unknown. Metabolomic techniques can comprehensively assess disturbances in metabolic pathways that reflect changes downstream from genomic, transcriptomic and proteomic systems. In the present study, we undertook a targeted metabolomic approach to determine a total of 187 prenominated metabolites in brain cortex tissue from wild type and rTg4510 animals (a mice model of tauopathy), in order to establish the association of metabolic pathways with cognitive impairment. This targeted metabolomic approach revealed significant differences in metabolite concentrations of transgenic mice. Brain glutamine, serotonin and sphingomyelin C18:0 were found to be predictors of memory impairment. These findings provide informative data for future research on AD, since some of them agree with pathological alterations observed in diseased humans.
Rights:	Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original.
Language:	Anglès
Document:	Article ; recerca ; Versió publicada
Subject:	Alzheimer's disease ; Cognitive impairment ; Metabolomics ; RTg4510 mice ; Tauopathy
Published in:	Metabolites, Vol. 10 Núm. 2 (february 2020) , p. 69, ISSN 2218-1989

DOI: 10.3390/metabo10020069
PMID: 32075035

16 p, 3.7 MB

The record appears in these collections:
Research literature > UAB research groups literature > Research Centres and Groups (research output) > Health sciences and biosciences > Institut de Recerca Sant Pau
Articles > Research articles
Articles > Published articles