Baseline chest computed tomography as standard of care in high-risk hematology patients
Stemler, Jannik (Partner Site Bonn-Cologne)
Bruns, Caroline (Partner Site Bonn-Cologne)
Mellinghoff, Sibylle C. (Partner Site Bonn-Cologne)
Alakel, Nael (University Hospital of Dresden)
Akan, Hamdi (Ankara University)
Ananda-rajah, Michelle (Monash University)
Auberger, Jutta (Onkologische Schwerpunktpraxis Freilassing)
Bojko, Peter (Red Cross Hospital Munich)
Chandrasekar, Pranatharthi.H. (Karmanos Cancer Center)
Chayakulkeeree, Methee (Mahidol University)
Cozzi, José A. (Hospital Provincial Del Centenario)
de Kort, Elizabeth A. (Radboud University Medical Center)
Groll, Andreas H. (University Children's Hospital)
Heath, Christopher H. (University of Western Australia)
Henze, Larissa (Rostock University Medical Center)
Jimenez, Marcos Hernandez (University of Carabobo)
Kanj, Souha S. (American University of Beirut Medical Center)
Khanna, Nina (University Hospital Basel (Basilea, Suïssa))
Koldehoff, Michael (University of Duisburg-Essen)
Lee, Dong-Gun. (Catholic University of Korea)
Mager, Alina (University Hospital Cologne)
Marchesi, Francesco (IRCCS Regina Elena National Cancer Institute)
Martino Bofarull, Rodrigo (Institut d'Investigació Biomèdica Sant Pau)
Nucci, Marcio (Universidade Federal do Rio de Janeiro)
Oksi, Jarmo (Turku University Hospital and University of Turku)
Pagano, Livio (Università Cattolica del Sacro Cuore)
Phillips, Bob (University of York)
Prattes, Juergen (Medical University of Graz)
Pyrpasopoulou, Athina (Hippokration Hospital)
Rabitsch, Werner (Medical University of Vienna)
Schalk, Enrico (Otto-von-Guericke University Magdeburg)
Schmidt-hieber, Martin (Carl-Thiem-Klinikum Cottbus)
Sidharthan, Neeraj (Amrita Institute of Medical Sciences)
Soler-Palacín, Pere (Hospital Universitari Vall d'Hebron)
Stern, Anat (Rambam Health Care Campus)
Weinbergerová, Barbora (Masaryk University and University Hospital Brno)
El Zakhem, Aline (American University of Beirut Medical Center)
Cornely, Oliver A. (ZKS Köln)
Koehler, Philipp (University of Cologne)
Universitat Autònoma de Barcelona

Date:	2020
Abstract:	Baseline chest computed tomography (BCT) in high-risk hematology patients allows for the early diagnosis of invasive pulmonary aspergillosis (IPA). The distribution of BCT implementation in hematology departments and impact on outcome is unknown. A web-based questionnaire was designed. International scientific bodies were invited. The estimated numbers of annually treated hematology patients, chest imaging timepoints and techniques, IPA rates, and follow-up imaging were assessed. In total, 142 physicians from 43 countries participated. The specialties included infectious diseases (n = 69; 49%), hematology (n = 68; 48%), and others (n = 41; 29%). BCT was performed in 57% (n = 54) of 92 hospitals. Upon the diagnosis of malignancy or admission, 48% and 24% performed BCT, respectively, and X-ray was performed in 48% and 69%, respectively. BCT was more often used in hematopoietic cell transplantation and in relapsed acute leukemia. European centers performed BCT in 59% and non-European centers in 53%. Median estimated IPA rate was 8% and did not differ between BCT (9%; IQR 5-15%) and non-BCT centers (7%; IQR 5-10%) (p = 0. 69). Follow-up computed tomography (CT) for IPA was performed in 98% (n = 90) of centers. In high-risk hematology patients, baseline CT is becoming a standard-of-care. Chest X-ray, while inferior, is still widely used. Randomized, controlled trials are needed to investigate the impact of BCT on patient outcome.
Rights:	Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original.
Language:	Anglès
Document:	Article ; recerca ; Versió publicada
Subject:	Antifungal prophylaxis ; Infection in hematology ; Invasive aspergillosis
Published in:	Journal of Fungi, Vol. 6 Núm. 1 (march 2020) , p. 36, ISSN 2309-608X

DOI: 10.3390/jof6010036
PMID: 32183235

13 p, 1.3 MB

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Research literature > UAB research groups literature > Research Centres and Groups (research output) > Health sciences and biosciences > Institut de Recerca Sant Pau
Articles > Research articles
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