Ten-year experience with penile prosthetic surgery for the treatment of erectile dysfunction : outcomes of a tertiary referral center and predictors of early prosthetic infection
Palmisano, Franco (Luigi Sacco University Hospital. ASST Fatebenefratelli-Sacco. Department of Urology)
Boeri, Luca (Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico (Milà, Itàlia))
Ievoli, Riccardo (University of Ferrara. Department of Economics and Management)
Sánchez-Curbelo, Josvany (Institut d'Investigació Biomèdica Sant Pau)
Spinelli, Matteo (IRCCS Foundation Ca' Granda Ospedale Maggiore Policlinico. University of Milan. Department of Urology)
Gregori, Andrea (Luigi Sacco University Hospital. ASST Fatebenefratelli-Sacco. Department of Urology)
Granata, Antonio (Luigi Sacco University Hospital. ASST Fatebenefratelli-Sacco. Department of Urology)
Ruiz-Castañé, Eduardo (Institut d'Investigació Biomèdica Sant Pau)
Montanari, Emanuele (IRCCS Foundation Ca' Granda Ospedale Maggiore Policlinico. University of Milan. Department of Urology)
Sarquella-Geli, Joaquim (Institut d'Investigació Biomèdica Sant Pau)

Date:	2022
Abstract:	We aimed to evaluate ten-year outcomes of penile prosthesis (PP) implantation for the treatment of erectile dysfunction and to assess predictors of early prosthetic infection (EPI). We identified 549 men who underwent 576 PP placements between 2008 and 2018. Univariate and multivariate analyses were used to identify potential predictors of EPI. An EPI predictive nomogram was developed. Thirty-five (6. 1%) cases of EPI were recorded with an explant rate of 3. 1%. In terms of satisfaction, 82. 0% of the patients defined themselves as 'satisfied,' while partner's satisfaction was 88. 3%. Diabetes (P = 0. 012), longer operative time (P = 0. 032), and reinterventions (P = 0. 048) were associated with EPI risk, while postoperative ciprofloxacin was inversely associated with EPI (P = 0. 014). Rifampin/gentamicin-coated 3-piece inflatable PP (r/g-c 3IPP) showed a higher EPI risk (P = 0. 019). Multivariate analyses showed a two-fold higher risk of EPI in diabetic patients, redo surgeries, or when a r/g-c 3IPP was used (all P < 0. 03). We showed that diabetes, longer operative time, and secondary surgeries were the risk factors for EPI. Postoperative ciprofloxacin was associated with a reduced risk of EPI, while r/g-c 3IPP had higher EPI rates without an increased risk of PP explant. After further validation, the proposed nomogram could be a useful tool for the preoperative counseling of PP implantation.
Rights:	Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra, i la creació d'obres derivades, sempre que no sigui amb finalitats comercials i que es distribueixin sota la mateixa llicència que regula l'obra original. Cal que es reconegui l'autoria de l'obra original.
Language:	Anglès
Document:	Article ; recerca ; Versió publicada
Subject:	Boston ; Coloplast Titan three-piece penile prosthesis ; Erectile dysfunction ; Impotence ; Inhibizone ; Patient satisfaction ; Penile prosthesis ; Prosthesis infection ; Rifampin soaking
Published in:	Asian Journal of Andrology, Vol. 24 Núm. 1 (january 2022) , p. 32-39, ISSN 1745-7262

DOI: 10.4103/aja.aja_27_21
PMID: 33975985

8 p, 546.7 KB

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Research literature > UAB research groups literature > Research Centres and Groups (research output) > Health sciences and biosciences > Institut de Recerca Sant Pau
Articles > Research articles
Articles > Published articles