Imaging and Genetic Tools for the Investigation of the Endocannabinoid System in the CNS
Kouchaeknejad, Armin (Universitat Autònoma de Barcelona. Institut de Neurociències)
Van Der Walt, Gunter (Universitat Autònoma de Barcelona. Institut de Neurociències)
De Donato, Maria Helena (Universitat Autònoma de Barcelona. Institut de Neurociències)
Puighermanal, Emma (Universitat Autònoma de Barcelona. Institut de Neurociències)

Date:	2023
Abstract:	As central nervous system (CNS)-related disorders present an increasing cause of global morbidity, mortality, and high pressure on our healthcare system, there is an urgent need for new insights and treatment options. The endocannabinoid system (ECS) is a critical network of endogenous compounds, receptors, and enzymes that contribute to CNS development and regulation. Given its multifaceted involvement in neurobiology and its significance in various CNS disorders, the ECS as a whole is considered a promising therapeutic target. Despite significant advances in our understanding of the ECS's role in the CNS, its complex architecture and extensive crosstalk with other biological systems present challenges for research and clinical advancements. To bridge these knowledge gaps and unlock the full therapeutic potential of ECS interventions in CNS-related disorders, a plethora of molecular-genetic tools have been developed in recent years. Here, we review some of the most impactful tools for investigating the neurological aspects of the ECS. We first provide a brief introduction to the ECS components, including cannabinoid receptors, endocannabinoids, and metabolic enzymes, emphasizing their complexity. This is followed by an exploration of cutting-edge imaging tools and genetic models aimed at elucidating the roles of these principal ECS components. Special emphasis is placed on their relevance in the context of CNS and its associated disorders.
Grants:	Ministerio de Economía y Competitividad RYC2020-029596-I Agencia Estatal de Investigación PID2021-125079OA-I00
Rights:	Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original.
Language:	Anglès
Document:	Article ; recerca ; Versió publicada
Subject:	Endocannabinoids ; CB1R ; Genetic mouse models ; Imaging tools ; CNS
Published in:	International journal of molecular sciences, Vol. 24 Núm. 21 (october 2023) , ISSN 1422-0067

DOI: 10.3390/ijms242115829
PMID: 37958825

49 p, 2.8 MB

The record appears in these collections:
Research literature > UAB research groups literature > Research Centres and Groups (research output) > Health sciences and biosciences > Institut de Neurociències (INc)
Articles > Research articles
Articles > Published articles