Plasma lipid profiles discriminate bacterial from viral infection in febrile children
Wang, Xinzhu (Imperial College London)
Nijman, Ruud Gerard (Imperial College London)
Camuzeaux, Stephane (IRDB Building)
Sands, Caroline (IRDB Building)
Jackson, Heather R. (Imperial College London)
Kaforou, Myrsini (Imperial College London)
Emonts, Marieke (Great North Children's Hospital)
Herberg, Jethro A. (Imperial College London)
Maconochie, Ian (Imperial College NHS Healthcare Trust)
Carrol, Enitan (Liverpool Health Partners)
Paulus, Stéphane (Liverpool Health Partners)
Zenz, Werner (Medical University of Graz)
Van der Flier, Michiel (Radboud University Medical Center)
de Groot, Ronald C.A. (Radboud University Medical Center)
Martinon-Torres, Federico (Hospital Clínico Universitario (Santiago de Compostela, Galícia))
Schlapbach, Luregn (Queensland Children's Hospital)
Pollard, AJ. (University of Oxford and the NIHR Oxford Biomedical Research Centre)
Fink, Colin (University of Warwick)
Kuijpers, T. W. (Emma Children's Hospital Academic Medical Center)
Anderson, Suzanne T. B. (London School of Hygiene & Tropical Medicine)
Lewis, Matthew R. (IRDB Building)
Levin, Michael (Imperial College London)
McClure, Myra (Imperial College London)
Gormley, Stuart (Imperial College London)
Hamilton, Shea (Imperial College London)
Hourmat, Bernardo (Imperial College London)
Hoggart, Clive (Imperial College London)
Sancho Shimizu, Vanessa (Imperial College London)
Wright, Victoria (Imperial College London)
Abdulla, Amina F. (Imperial College London)
Agapow, Paul Michael (Imperial College London)
Bartlett, Maeve (Imperial College London)
Bellos, Evangelos (Imperial College London)
Eleftherohorinou, Hariklia (Imperial College London)
Galassini, Rachel (Imperial College London)
Inwald, David (Imperial College London)
Mashbat, Meg (Imperial College London)
Menikou, Stephanie (Imperial College London)
Mustafa, Sobia (Imperial College London)
Nadel, Simon (Imperial College London)
Rahman, Rahmeen (Imperial College London)
Thakker, Clare (Imperial College London)
Coin, Lachlan (Imperial College London)
Bokhandi, Sumit S. (Poole Hospital NHS Foundation Trust)
Power, Sue (Poole Hospital NHS Foundation Trust)
Barham, Heather (Poole Hospital NHS Foundation Trust)
Pathan, Nazima (Cambridge University Hospitals NHS Trust)
Ridout, Jenna (Cambridge University Hospitals NHS Trust)
White, Deborah K. (Cambridge University Hospitals NHS Trust)
Thurston, Sarah (Cambridge University Hospitals NHS Trust)
Faust, Saul (University Hospital Southampton)
Patel, Sanjay Valabh (University Hospital Southampton)
McCorkell, Jenni (University Hospital Southampton)
Davies, Patrick (Nottingham University Hospital NHS Trust)
Crate, Lindsay (Nottingham University Hospital NHS Trust)
Navarra, Helen (Nottingham University Hospital NHS Trust)
Carter, Stephanie (Nottingham University Hospital NHS Trust)
Ramaiah, Raghu (University Hospitals of Leicester NHS Trust)
Patel, Rekha (University Hospitals of Leicester NHS Trust)
Tuffrey, Catherine (Portsmouth Hospitals NHS Trust)
Gribbin, Andrew (Portsmouth Hospitals NHS Trust)
McCready, Sharon (Portsmouth Hospitals NHS Trust)
Peters, Mark (Great Ormond Street Hospital for Children (Londres))
Hardy, Katie (Great Ormond Street Hospital for Children (Londres))
Standing, Fran (Great Ormond Street Hospital for Children (Londres))
O'Neill, Lauren (Great Ormond Street Hospital for Children (Londres))
Abelake, Eugenia (Great Ormond Street Hospital for Children (Londres))
Deep, Akash (King's College Hospital NHS Foundation Trust)
Nsirim, Eniola (King's College Hospital NHS Foundation Trust)
Willis, Louise (Oxford University Hospitals NHS Foundation Trust)
Young, Zoe (Oxford University Hospitals NHS Foundation Trust)
Royad, C. (Kettering General Hospital NHS Foundation Trust)
White, Sonia (Kettering General Hospital NHS Foundation Trust)
Fortune, Peter-Marc (Central Manchester NHS Trust)
Hudnott, Phil (Central Manchester NHS Trust)
Álvez González, Fernando (Hospital Clínico Universitario (Santiago de Compostela, Galícia))
Barral-Arca, Ruth (Hospital Clínico Universitario (Santiago de Compostela, Galícia))
Cebey-López, Miriam (Hospital Clínico Universitario (Santiago de Compostela, Galícia))
Curras-Tuala, MJ. (Hospital Clínico Universitario (Santiago de Compostela, Galícia))
García, Natalia (Hospital Clínico Universitario (Santiago de Compostela, Galícia))
Vicente, Luisa García (Hospital Clínico Universitario (Santiago de Compostela, Galícia))
Gómez-Carballa, Alberto (Hospital Clínico Universitario (Santiago de Compostela, Galícia))
Gomez-Rial, Jose (Hospital Clínico Universitario (Santiago de Compostela, Galícia))
Grela Beiroa, Andrea (Hospital Clínico Universitario (Santiago de Compostela, Galícia))
Justicia-Grande, Antonio (Hospital Clínico Universitario (Santiago de Compostela, Galícia))
Iglesias, Pilar Leboráns (Hospital Clínico Universitario (Santiago de Compostela, Galícia))
Martinez-Santos, Alba-Elena (Hospital Clínico Universitario (Santiago de Compostela, Galícia))
MartinónTorres, Nazareth (Hospital Clínico Universitario (Santiago de Compostela, Galícia))
Sánchez, José María (Hospital Clínico Universitario (Santiago de Compostela, Galícia))
Morillo Gutiérrez, Beatriz (Hospital Clínico Universitario (Santiago de Compostela, Galícia))
Pérez, Belén Mosquera (Hospital Clínico Universitario (Santiago de Compostela, Galícia))
Pacheco, Pablo Obando (Hospital Clínico Universitario (Santiago de Compostela, Galícia))
Pardo-Seco, Jacobo (Hospital Clínico Universitario (Santiago de Compostela, Galícia))
Pischedda, Sara (Hospital Clínico Universitario (Santiago de Compostela, Galícia))
Rivero Calle, Irene (Hospital Clínico Universitario (Santiago de Compostela, Galícia))
Rodríguez-Tenreiro, Carmen (Hospital Clínico Universitario (Santiago de Compostela, Galícia))
Redondo Collazo, Lorenzo (Hospital Clínico Universitario (Santiago de Compostela, Galícia))
Ellacuriagal, Antonio Salas (Hospital Clínico Universitario (Santiago de Compostela, Galícia))
Serén Fernández, Sonia (Hospital Clínico Universitario (Santiago de Compostela, Galícia))
Silva, María Del Sol Porto (Hospital Clínico Universitario (Santiago de Compostela, Galícia))
Vega, Ana Karina (Universidade de Santiago de Compostela (USC))
Vilanova-Trillo, Lucía (Hospital Clínico Universitario (Santiago de Compostela, Galícia))
Salas, Antonio (Hospital Clínico Universitario (Santiago de Compostela, Galícia))
Reyes, Susana Beatriz (Hospital Clínico Universitario Virgen de la Arrixaca (El Palmar, Múrcia))
León-León, María Cruz (Hospital Clínico Universitario Virgen de la Arrixaca (El Palmar, Múrcia))
Mingorance, Álvaro Navarro (Hospital Clínico Universitario Virgen de la Arrixaca (El Palmar, Múrcia))
Barrios, Xavier Gabaldó (Hospital Clínico Universitario Virgen de la Arrixaca (El Palmar, Múrcia))
Oñate Vergara, Eider (Hospital de Donostia (Sant Sebastià, País Basc))
Concha-Torre, Andres (Hospital Universitario Central de Asturias)
Vivanco, Ana (Hospital Universitario Central de Asturias)
Fernández, Reyes (Hospital Universitario Central de Asturias)
Giménez-Sánchez, Francisco (Complejo Hospitalario Torrecárdenas (Almeria))
Forte, Miguel Sánchez (Complejo Hospitalario Torrecárdenas (Almeria))
Rojo, Pablo (Hospital 12 de Octubre (Madrid))
Contreras, J. Ruiz (Hospital 12 de Octubre (Madrid))
Palacios, Alba (Hospital 12 de Octubre (Madrid))
Ibarrondo, Cristina Epalza (Hospital 12 de Octubre (Madrid))
Cooke, Elizabeth Fernández (Hospital 12 de Octubre (Madrid))
Navarro, Marisa (Hospital General Universitario Gregorio Marañón)
Álvarez, Cristina Álvarez (Hospital General Universitario Gregorio Marañón)
Lozano, María José (Hospital General Universitario Gregorio Marañón)
Carreras, Eduardo (Hospital de la Santa Creu i Sant Pau (Barcelona, Catalunya))
Brió Sanagustín, Sonia (Institut d'Investigació Biomèdica Sant Pau)
Neth, Olaf (Hospital Universitario Virgen del Rocío (Sevilla, Andalusia))
Padilla, Ma del Carmen Martínez (Complejo Hospitalario de Jaén)
Tato, Luis Manuel Prieto (Hospital Universitario de Getafe (Madrid))
Guillén, Sara (Hospital Universitario de Getafe (Madrid))
Fernandez Silveira, Laura (Hospital Universitari i Politècnic La Fe (València))
Moreno, David (Hospital Regional Universitario Carlos Haya (Málaga))
van Furth, Marceline (Vrije Universiteit University Medical Center)
Boeddha, Navin P. (Sophia Children's Hospital)
Driessen, Gertjan Jan A. (Sophia Children's Hospital)
Hazelzet, Jan (Sophia Children's Hospital)
Pajkrt, Dasja (Emma Children's Hospital Academic Medical Center)
Sanders, Elisabeth A. M. (Wilhelmina Children's Hospital)
van de Beek, Diederik (University of Amsterdam)
van der Ende, Arie (University of Amsterdam)
Philipsen, H.L.A. (Vrije Universiteit University Medical Center)
Adeel, Abdul O.A. (Kennemer Gasthuis)
Breukels, Meike A. (Elkerliek Hospital)
Brinkman, Daniëlle M.C. (Alrijne Hospital)
de Korte, Carla C.M.M. (Beatrix Hospital)
de Vries, Esther (Diakonessenhuis)
de Waal, Wouter J. (Maasziekenhuis Pantein)
Dekkers, Roel (Maasziekenhuis Pantein)
Dings-Lammertink, Anouk (Gelre Hospitals)
Doedens, Rienus A. (Martini Hospital)
Donker, AlbertineE. (Maxima Medical Center)
Dousma, Mieke (Gemini Hospital)
Faber, Tina E. (Medical Center Leeuwarden)
Gerrits, Gerardus Peter Jm M. (Canisius-Wilhelmina Hospital)
Gerver, Jan A.M. (Rode Kruis Hospital)
Heidema, Jojanneke (St. Antonius Hospital)
Veen, J. Homan-van der (Deventer Hospital)
Jacobs, Monique A.M. (Slingeland Hospital)
Jansen, Nicolaas Johannes Georgius (Wilhelmina Children's Hospital)
Kawczynski, Pawel (Refaja Hospital)
Klucovska, Kristine (Bethesda Hospital)
Kneyber, Martin Christiaan Jacques (Beatrix Children's hospital)
Koopman-Keemink, Yvonne (Juliana Children's Hospital)
Langenhorst, Veerle J. (Isala Hospital)
Leusink, José (Bernhoven Hospital)
Loza, Bettina F. (VieCuri Medical Center)
Merth, Istvan T. (Ziekenhuisgroep Twente)
Miedema, Carien J. (Catharina Hospital)
Neeleman, Chris (Vrije Universiteit University Medical Center)
Noordzij, Jeroen G. (Reinier de Graaf Gasthuis)
Obihara, Charlie C.C. (ETZ Elisabeth)
van Overbeek - van Gils, A. Lidy T. (Scheper Hospital)
Poortman, Geriska H. (St. Jansdal Hospital)
Potgieter, Steph T. (Laurentius Hospital)
Potjewijd, Joke (Isala Diaconessenhuis)
Rosias, Philippe P.R. (Zuyderland Medical Center)
Sprong, Tom (Canisius-Wilhelmina Hospital)
ten Tussher, Gavin W. (Westfriesgasthuis)
Thio, Bernard J. (Medisch Spectrum Twente)
Tramper-Stranders, Gerdien A. (St. Franciscus Gasthuis)
van Deuren, M. (Vrije Universiteit University Medical Center)
van der Meer, H. (Hospital Clínico Universitario (Santiago de Compostela, Galícia))
van Kuppevelt, A.J.M. (Streekziekenhuis Koningin Beatrix)
van Wermeskerken, A.M. (Flevo Hospital)
Verwijs, W.A. (Zuwe Hofpoort Hospital)
Wolfs, T.F.W. (Newcastle University)
Agyeman, Philipp (University of Bern)
Aebi, C. (University of Bern)
Berger, C. (University Children's Hospital Zurich)
Giannoni, E. (Lausanne University Hospital)
Stocker, M. (Children's Hospital Lucerne)
Posfay-Barbe, K.M. (Geneva University Hospitals)
Heininger, U. (University of Basel Children's Hospital)
Bernhard-Stirnemann, S. (Children's Hospital Aarau)
Niederer-Loher, A. (Children's Hospital of Eastern Switzerland St. Gallen)
Kahlert, C. (Children's Hospital of Eastern Switzerland St. Gallen)
Hasters, P. (University Hospital Zurich (Suïssa))
Relly, C. (University Children's Hospital Zurich)
Baer, W. (Children's Hospital Chur)
Frederick, H. (Alder Hey Children's Hospital)
Jennings, R. (Alder Hey Children's Hospital)
Johnston, J. (Alder Hey Children's Hospital)
Kenwright, R. (Alder Hey Children's Hospital)
Pinnock, Elli (University of Warwick)
Agbeko, R. (Imperial College NHS Healthcare Trust)
Secka, Fatou (London School of Hygiene & Tropical Medicine)
Bojang, Kalifa (London School of Hygiene & Tropical Medicine)
Sarr, Isatou (London School of Hygiene & Tropical Medicine)
Kebbeh, Ngange (London School of Hygiene & Tropical Medicine)
Sey, Gibbi (London School of Hygiene & Tropical Medicine)
Momodou, None
khan, Saidy (London School of Hygiene & Tropical Medicine)
Cole, Fatoumata (London School of Hygiene & Tropical Medicine)
Thomas, Gilleh (London School of Hygiene & Tropical Medicine)
Antonio, Martin (London School of Hygiene & Tropical Medicine)
Klobassa, Daniela S. (University Medical Center Utrecht)
Binder, Alexander (University Medical Center Utrecht)
Schweintzger, Nina (University Medical Center Utrecht)
Sagmeister, Manfred (University Medical Center Utrecht)
Baumgart, Hinrich (Medical University Graz)
Baumgartner, Markus (General Hospital of Steyr)
Behrends, Uta (Technische Universität München (TUM))
Biebl, Ariane (Medical Faculty of the Johannes Kepler University)
Birnbacher, Robert (LKH Villach)
Blanke, Jan-Gerd (Hospital Ludmillenstift)
Boelke, Carsten (Hospital for Children's and Youth Medicine. Oberschwabenklinik)
Breuling, Kai (Technische Universität München (TUM))
Brunner, Jürgen (Medical University Innsbruck)
Buller, Maria (Sana Hanse-Klinikum Wismar)
Dahlem, Peter (Medical Center Coburg)
Dietrich, Beate (University Medicine Rostock)
Eber, Ernst (Medical University Graz)
Elias, Johannes (University of Würzburg)
Emhofer, Josef (General Hospital of Steyr)
Etschmaier, Rosa (Medical University Graz)
Farr, Sebastian (Orthopedic Hospital Speising)
Girtler, Ylenia (Regional Hospital Bolzano)
Grigorow, Irina (General Hospital Hochsteiermark/Leoben)
Heimann, Konrad (RWTH Aachen)
Ihm, Ulrike (Donauspital Vienna)
Jaros, Zdenek (General Public Hospital)
Kalhoff, Hermann (Pediatric Clinic Dortmund)
Kaulfersch, Wilhelm (Klinikum Klagenfurt am Wörthersee)
Kemen, Christoph (Catholic Children's Hospital Wilhelmstift)
Klocker, Nina (Krankenhaus Dornbirn)
Köster, Bernhard (Maerkische Kliniken)
Kohlmaier, B. (Medical University Graz)
Komini, Eleni (Schwarzwald-Baar-Hospital)
Kramer, Lydia (Technische Universität München (TUM))
Neubert, Antje (University Hospital Erlangen (Alemanya))
Ortner, Daniel (Medical University of Salzburg)
Pescollderungg, Lydia (Regional Hospital Bolzano)
Pfurtscheller, Klaus (Medical University Graz)
Reiter, Karl (Ludwig-Maximilians-Universitaet)
Ristic, Goran (Mother and Child Health Care Institute of Serbia)
Rödl, Siegfried (Medical University Graz)
Sellner, Andrea (Medical University Graz)
Sonnleitner, Astrid (Medical University Graz)
Sperl, Matthias (Medical University Graz)
Stelzl, Wolfgang (Landeskrankenhaus Feldkirch)
Till, Holger Karl H. (Medical University Graz)
Trobisch, Andreas (Medical University Graz)
Vierzig, Anne (University of Cologne)
Vogel, Ulrich (Medical University Graz)
Weingarten, Christina (Department of Pediatrics and Adolescent Medicine Wilheminenspital)
Welke, Stefanie (Municipal Hospital Karlsruhe)
Wimmer, Andreas (Hospital of the Sisters of Mercy Ried)
Wintergerst, Uwe (Hospital St. Josef)
Wüller, Daniel (Christophorus Kliniken Coesfeld Clinic for Pediatrics)
Zaunschirm, Andrew (Karl Landsteiner University of Health Sciences)
Ziuraite, Ieva (Children's Hospital)
Žukovskaja, Veslava (Children's Hospital)
Universitat Autònoma de Barcelona

Date:	2019
Abstract:	Fever is the most common reason that children present to Emergency Departments. Clinical signs and symptoms suggestive of bacterial infection are often non-specific, and there is no definitive test for the accurate diagnosis of infection. The 'omics' approaches to identifying biomarkers from the host-response to bacterial infection are promising. In this study, lipidomic analysis was carried out with plasma samples obtained from febrile children with confirmed bacterial infection (n = 20) and confirmed viral infection (n = 20). We show for the first time that bacterial and viral infection produces distinct profile in the host lipidome. Some species of glycerophosphoinositol, sphingomyelin, lysophosphatidylcholine and cholesterol sulfate were higher in the confirmed virus infected group, while some species of fatty acids, glycerophosphocholine, glycerophosphoserine, lactosylceramide and bilirubin were lower in the confirmed virus infected group when compared with confirmed bacterial infected group. A combination of three lipids achieved an area under the receiver operating characteristic (ROC) curve of 0. 911 (95% CI 0. 81 to 0. 98). This pilot study demonstrates the potential of metabolic biomarkers to assist clinicians in distinguishing bacterial from viral infection in febrile children, to facilitate effective clinical management and to the limit inappropriate use of antibiotics.
Rights:	Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original.
Language:	Anglès
Document:	Article ; recerca ; Versió publicada
Subject:	Diagnostic markers ; Metabolomics
Published in:	Scientific reports, Vol. 9 Núm. 1 (january 2019) , p. 17714, ISSN 2045-2322

DOI: 10.1038/s41598-019-53721-1
PMID: 31776453

13 p, 1.5 MB

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