Association between gestational weight gain, gestational diabetes risk, and obstetric outcomes : A randomized controlled trial post hoc analysis
Simmons, David (Western Sydney University)
Devlieger, Roland (GasthuisZusters Antwerpen Sint-Augustinus)
van Assche, Andre (KU Leuven)
Galjaard, Sander (University Medical Centre Rotterdam)
Corcoy i Pla, Rosa (Institut d'Investigació Biomèdica Sant Pau)
Adelantado, Juan M. (Institut d'Investigació Biomèdica Sant Pau)
Dunne, Fidelma (National University of Ireland)
Desoye, Gernot (Medizinische Universitaet Graz)
Kautzky-Willer, Alexandra (Addenbrookes Hospital (Cambridge, Regne Unit))
Damm, Peter (University of Copenhagen)
Mathiesen, Elisabeth Reinhardt (University of Copenhagen)
Jensen, Dorte M. (University of Southern Denmark)
Andersen, Lise-Lotte (University of Southern Denmark)
Lapolla, Annunziata (Università degli Studi di Padova)
Dalfra, Maria Grazia (Università degli Studi di Padova)
Bertolotto, Alessandra (Università di Pisa)
Wender-Ozegowska, Ewa (Poznan University of Medical Sciences)
Zawiejska, Agnieszka (Poznan University of Medical Sciences)
Hill, David (Recherche en Santé Lawson SA)
Snoek, Frank J. (Vrije Universiteit Amsterdam)
Van Poppel, Mireille (University of Graz)
Universitat Autònoma de Barcelona

Date:	2018
Abstract:	Excess gestational weight gain (GWG) is associated with the development of gestational diabetes mellitus (GDM). Lifestyle trials have not achieved much GWG limitation, and have largely failed to prevent GDM. We compared the effect of substantial GWG limitation on maternal GDM risk. Pregnant women with a body mass index (BMI) ≥29 kg/m <20 weeks gestation without GDM (n = 436) were randomized, in a multicenter trial, to usual care (UC), healthy eating (HE), physical activity (PA), or HE and PA lifestyle interventions. GWG over the median was associated with higher homeostasis model assessment insulin resistance (HOMA-IR) and insulin secretion (Stumvoll phases 1 and 2), a higher fasting plasma glucose (FPG) at 24-28 weeks (4. 66 ± 0. 43 vs. 4. 61 ± 0. 40 mmol/L, p < 0. 01), and a higher rate of caesarean section (38% vs. 27% p < 0. 05). The GWG over the median at 35-37 weeks was associated with a higher rate of macrosomia (25% vs. 16%, p < 0. 05). A post hoc comparison among women from the five sites with a GWG difference.
Rights:	Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original.
Language:	Anglès
Document:	Article ; recerca ; Versió publicada
Subject:	Gestational diabetes mellitus ; Healthy eating ; Lifestyle intervention ; Motivational interviewing ; Overweight ; Physical activity ; Pregnancy ; Prevention ; Randomised controlled trial
Published in:	Nutrients, Vol. 10 Núm. 11 (november 2018) , p. 1568, ISSN 2072-6643

DOI: 10.3390/nu10111568
PMID: 30360536

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Research literature > UAB research groups literature > Research Centres and Groups (research output) > Health sciences and biosciences > Institut de Recerca Sant Pau
Articles > Research articles
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