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| Home > Articles > Published articles > Circulating metabolomic profile can predict dyslipidemia in HIV patients undergoing antiretroviral therapy |
(Hospital Universitari Joan XXIII de Tarragona) (Universitat Rovira i Virgili) (Institut d'Investigació Biomèdica Sant Pau) (Hospital Universitari Joan XXIII de Tarragona) (Hospital Universitari Joan XXIII de Tarragona) (Universidad de Sevilla) (Hospital General de Elche y Universidad Miguel Hernández) (Hospital Universitari Joan XXIII de Tarragona) (Hospital Universitari Joan XXIII de Tarragona)| Date: | 2018 |
| Abstract: | Dyslipidemia in HIV-infected patients is unique and pathophysiologically associated with host factors, HIV itself and the use of antiretroviral therapy (ART). The use of nuclear magnetic resonance spectroscopy (NMR) provides additional data to conventional lipid measurements concerning the number of lipoprotein subclasses and particle sizes. To investigate the ability of lipoprotein profile, we used a circulating metabolomic approach in a cohort of 103 ART-naive HIV-infected patients, who were initiating non-nucleoside analogue transcriptase inhibitor (NNRTI)-based ART, and we subsequently followed up these patients for 36 months. Univariate and multivariate analyses were performed to evaluate the predictive power of NMR spectroscopy. VLDL-metabolism (including VLDL lipid concentrations, sizes, and particle numbers), total triglycerides and lactate levels resulted in good classifiers of dyslipidemia (AUC 0. 903). Total particles/HDL-P ratio was significantly higher in ART-associated dyslipidemia compared to ART-normolipidemia (p = 0. 001). Large VLDL-Ps were positively associated with both LDL-triglycerides (ρ 0. 682, p < 0. 001) and lactate concentrations (ρ 0. 416, p < 0. 001), the last one a marker of mitochondrial low oxidative capacity. Our data suggest that circulating metabolites have better predictive values for HIV/ART-related dyslipidemia onset than do the biochemical markers associated with conventional lipid measurements. NMR identifies changes in VLDL-P, lactate and LDL-TG as potential clinical markers of baseline HIV-dyslipidemia predisposition. Differences in circulating metabolomics, especially differences in particle size, are indicators of important derangements of mitochondrial function that are linked to ART-related dyslipidemia. |
| Grants: | Ministerio de Ciencia e Innovación PI11/02512 Ministerio de Economía y Competitividad PI12/02283 Ministerio de Economía y Competitividad PI13/02256 Ministerio de Economía y Competitividad PI16/00684 Ministerio de Economía y Competitividad PI16/00503 Ministerio de Economía y Competitividad PI16/01740 Ministerio de Economía y Competitividad RD12/0017/0005 Ministerio de Economía y Competitividad RD12/0017/0014 Ministerio de Economía y Competitividad RD12/0017/0023 Ministerio de Economía y Competitividad RD16/0025/0006 Ministerio de Economía y Competitividad RD16/0025/0020 Ministerio de Economía y Competitividad RD16/0025/0038 Ministerio de Economía y Competitividad CPII13/00037 |
| Rights: | Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, i la comunicació pública de l'obra, sempre que no sigui amb finalitats comercials, i sempre que es reconegui l'autoria de l'obra original. No es permet la creació d'obres derivades.  |
| Language: | Anglès |
| Document: | Article ; recerca ; Versió publicada |
| Subject: | ART therapy ; Dyslipidemia ; HIV ; Lipids ; Lipoproteins ; Metabolomics ; NMR |
| Published in: | Atherosclerosis, Vol. 273 (june 2018) , p. 28-36, ISSN 1879-1484 |
