Cost-effectiveness of healthy eating and/or physical activity promotion in pregnant women at increased risk of gestational diabetes mellitus : Economic evaluation alongside the DALI study, a European multicenter randomized controlled trial
Broekhuizen, Karen (Vrije Universiteit Amsterdam)
Simmons, David (Addenbrookes Hospital (Cambridge, Regne Unit))
Devlieger, Roland (Katholieke Universiteit Leuven)
van Assche, André (Katholieke Universiteit Leuve)
Jans, Goele (Katholieke Universiteit Leuven)
Galjaard, Sander (University Medical Centre Rotterdam)
Corcoy i Pla, Rosa (Institut d'Investigació Biomèdica Sant Pau)
Adelantado, Juan M (Instituto de Salud Carlos III)
Dunne, Fidelma (National University of Ireland)
Desoye, Gernot (Medizinische Universitaet Graz)
Harreiter, Jürgen. (Medical University of Vienna)
Kautzky-Willer, Alexandra (Medical University of Vienna)
Damm, Peter (University of Copenhagen)
Mathiesen, Elisabeth R. (University of Copenhagen)
Jensen, Dorte M. (University of Southern Denmark)
Andersen, Lise-Lotte (University of Southern Denmark)
Lapolla, Annunziata (Universita Degli Studi di Padova)
Dalfra, Maria Grazia (Universita Degli Studi di Padova)
Bertolotto, Alessandra (Azienda Ospedaliero Universitaria - Pisa)
Wender-Ozegowska, Ewa (Poznan University of Medical Sciences)
Zawiejska, Agnieszka (Poznan University of Medical Sciences)
Hill, David (Recherche en Santé Lawson SA)
Snoek, Frank J. (Academic Medical Centre)
Jelsma, Judith G. M (VU University Medical Centre)
Bosmans, J.E. (Vrije Universiteit Amsterdam)
van Poppel, M.N.M (University of Graz)
van Dongen, Johanna M. (Vrije Universiteit Amsterdam)
Universitat Autònoma de Barcelona

Date:	2018
Abstract:	Gestational diabetes mellitus (GDM) is associated with perinatal health risks to both mother and offspring, and represents a large economic burden. The DALI study is a multicenter randomized controlled trial, undertaken to add to the knowledge base on the effectiveness of interventions for pregnant women at increased risk for GDM. The purpose of this study was to evaluate the cost-effectiveness of the healthy eating and/or physical activity promotion intervention compared to usual care among pregnant women at increased risk of GDM from a societal perspective. An economic evaluation was performed alongside a European multicenter-randomized controlled trial. A total of 435 pregnant women at increased risk of GDM in primary and secondary care settings in nine European countries, were recruited and randomly allocated to a healthy eating and physical activity promotion intervention (HE + PA intervention), a healthy eating promotion intervention (HE intervention), or a physical activity promotion intervention (PA intervention). Main outcome measures were gestational weight gain, fasting glucose, insulin resistance (HOMA-IR), quality adjusted life years (QALYs), and societal costs. Between-group total cost and effect differences were not significant, besides significantly less gestational weight gain in the HE + PA group compared with the usual care group at 35-37 weeks (2. 3;95%CI:-3. 7;-0. 9). Cost-effectiveness acceptability curves indicated that the HE + PA intervention was the preferred intervention strategy. At 35-37 weeks, it depends on the decision-makers' willingness to pay per kilogram reduction in gestational weight gain whether the HE + PA intervention is cost-effective for gestational weight gain, whereas it was not cost-effective for fasting glucose and HOMA-IR. After delivery, the HE + PA intervention was cost-effective for QALYs, which was predominantly caused by a large reduction in delivery-related costs. Healthy eating and physical activity promotion was found to be the preferred strategy for limiting gestational weight gain. As this intervention was cost-effective for QALYs after delivery, this study lends support for broad implementation.
Rights:	Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original.
Language:	Anglès
Document:	Article ; recerca ; Versió publicada
Subject:	Cost-effectiveness ; Economic evaluation ; Gestational diabetes ; Lifestyle intervention ; Pregnant women
Published in:	The international journal of behavioral nutrition and physical activity, Vol. 15 Núm. 1 (14 2018) , p. 23, ISSN 1479-5868

DOI: 10.1186/s12966-018-0643-y
PMID: 29540227

12 p, 1.1 MB

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Research literature > UAB research groups literature > Research Centres and Groups (research output) > Health sciences and biosciences > Institut de Recerca Sant Pau
Articles > Research articles
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