Predictors of poor health-related quality of life among people living with HIV aged ≥60 years in the PISCIS cohort : Findings from the Vive+ project
Bruguera Riera, Andreu (Institut Germans Trias i Pujol)
Egea Cortés, Laia (Institut Germans Trias i Pujol)
Mesías-Gazmuri, Jocelyn (Institut Germans Trias i Pujol)
Palacio-Vieira, Jorge (Institut Germans Trias i Pujol)
García Forero, Carlos (Universitat Internacional de Catalunya)
Miranda Sánchez, Cristina (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol)
Saumoy, Maria (Hospital Universitari de Bellvitge)
Fernández, E. (Institut d'Investigacions Biomèdiques August Pi i Sunyer)
Navarro, Gemma (Parc Taulí Hospital Universitari. Institut d'Investigació i Innovació Parc Taulí (I3PT))
Ortí, Amat-Joaquim (Hospital de Tortosa Verge de la Cinta)
Miró, Josep (Instituto de Salud Carlos III)
Casabona-Barbarà, Jordi (Institut Germans Trias i Pujol)
Reyes-Urueña, Juliana (Centre d'Estudis Epidemiològics sobre el VIH/SIDA de Catalunya)
Universitat Autònoma de Barcelona
Fecha: |
2023 |
Resumen: |
Introduction: Advancements in and accessibility to effective antiretroviral therapy has improved the life expectancy of people living with HIV, increasing the proportion of people living with HIV reaching older age (≥60 years), making this population's health-related quality of life (HRQoL) more relevant. Our aim was to identify the determinants of poor HRQoL in people living with HIV aged ≥60 years and compare them with those of their younger counterparts. Methods: We used data from the 'Vive+' study, a cross-sectional survey conducted between October 2019 and March 2020, nested within the PISCIS cohort of people living with HIV in Catalonia and the Balearic Islands, Spain. We used the 12-item short-form survey (SF-12), divided into a physical component summary (PCS) and a mental component summary (MCS), to evaluate HRQoL. We used the least absolute shrinkage and selection operator for variable selection and used multivariable regression models to identify predictors. Results: Of the 1060 people living with HIV (78. 6% males) who participated in the study, 209 (19. 7%) were aged ≥60 years. When comparing older people living with HIV (≥60 years) and their younger counterparts, older people exhibited a worse PCS (median 51. 3 [interquartile range {IQR} 46. 0-58. 1] vs. 46. 43 [IQR 42. 5-52. 7], p < 0. 001) but a similar MCS (median 56. 0 [IQR 49. 34-64. 7] vs. 57. 0 [IQR 48. 9-66. 3], p = 0. 476). In the multivariable analysis, cognitive function correlated with a PCS (β correlation factor [β] −0. 18, p = 0. 014), and depressive symptoms and satisfaction with social role correlated with an MCS (β 0. 61 and β −0. 97, respectively, p < 0. 001) in people living with HIV aged ≥60 years. Conclusion: Depressive symptoms, poor cognitive function, and lower satisfaction with social roles predict poorer HRQoL in older people living with HIV. These factors need to be considered when designing targeted interventions. |
Nota: |
Altres ajuts: acords transformatius de la UAB |
Derechos: |
Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, sempre que no sigui amb finalitats comercials, i sempre que es reconegui l'autoria de l'obra original. |
Lengua: |
Anglès |
Documento: |
Article ; recerca ; Versió publicada |
Materia: |
Ageing ;
AIDS ;
Cognitive function ;
Depressive symptoms ;
Health-related quality of life ;
HIV |
Publicado en: |
HIV Medicine, 2023 , ISSN 1468-1293 |
DOI: 10.1111/hiv.13590
PMID: 38092529
El registro aparece en las colecciones:
Documentos de investigación >
Documentos de los grupos de investigación de la UAB >
Centros y grupos de investigación (producción científica) >
Ciencias de la salud y biociencias >
Institut d'Investigació en Ciencies de la Salut Germans Trias i Pujol (IGTP)Documentos de investigación >
Documentos de los grupos de investigación de la UAB >
Centros y grupos de investigación (producción científica) >
Ciencias de la salud y biociencias >
Instituto de Investigación e Innovación Parc Taulí (I3PT) Artículos >
Artículos de investigaciónArtículos >
Artículos publicados
Registro creado el 2024-01-24, última modificación el 2024-05-06