Synaptic proteomics as a means to identify the molecular basis of mental illness : Are we getting there?
Reig-Viader, R (Institut d'Investigació Biomèdica Sant Pau)
Sindreu, Carlos (Universitat de Barcelona)
Bayés, Àlex (Institut d'Investigació Biomèdica Sant Pau)
Universitat Autònoma de Barcelona

Date:	2018
Abstract:	Synapses are centrally involved in many brain disorders, particularly in psychiatric and neurodevelopmental ones. However, our current understanding of the proteomic alterations affecting synaptic performance in the majority of mental illnesses is limited. As a result, novel pharmacotherapies with improved neurological efficacy have been scarce over the past decades. The main goal of synaptic proteomics in the context of mental illnesses is to identify dysregulated molecular mechanisms underlying these conditions. Here we reviewed and performed a meta-analysis of previous neuroproteomic research to identify proteins that may be consistently dysregulated in one or several mental disorders. Notably, we found very few proteins reproducibly altered among independent experiments for any given condition or between conditions, indicating that we are still far from identifying key pathophysiological mechanisms of mental illness. We suggest that future research in the field will require higher levels of standardization and larger-scale experiments to address the challenge posed by biological and methodological variability. We strongly believe that more resources should be placed in this field as the need to identify the molecular roots of mental illnesses is highly pressing.
Grants:	Ministerio de Economía y Competitividad BFU2012-34398 Ministerio de Economía y Competitividad BFU2015-69717-P Ministerio de Ciencia e Innovación RYC-2011-08391 Ministerio de Ciencia e Innovación RYC-2011-08026
Rights:	Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, i la comunicació pública de l'obra, sempre que no sigui amb finalitats comercials, i sempre que es reconegui l'autoria de l'obra original. No es permet la creació d'obres derivades.
Language:	Anglès
Document:	Article de revisió ; recerca ; Versió publicada
Subject:	Meta-analysis ; Neurodevelopmental disorders ; Proteomics ; Psychiatric disorders ; Synapse
Published in:	Progress in neuro-psychopharmacology & biological psychiatry, Vol. 84 (august 2018) , p. 353-361, ISSN 1878-4216

DOI: 10.1016/j.pnpbp.2017.09.011
PMID: 28941771

9 p, 923.4 KB

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Research literature > UAB research groups literature > Research Centres and Groups (research output) > Health sciences and biosciences > Institut de Recerca Sant Pau
Articles > Research articles
Articles > Published articles