Characterization of the CPAP-treated patient population in Catalonia
Turino, Cecilia (Hospital Universitari Arnau de Vilanova i Santa Maria)
Bertran, Sandra (Hospital Universitari Arnau de Vilanova i Santa Maria)
Gavaldá, Ricard (Universitat Politècnica de Catalunya. BarcelonaTech)
Teixidó, Ivan (Universitat de Lleida)
Woehrle, Holger (Respiratory Center Ulm)
Rué, Montserrat (Institut de Recerca Biomèdica de Lleida)
Solsona, Francesc (Universitat de Lleida)
Escarrabill, Joan (Hospital Clínic i Provincial de Barcelona)
Colls, Cristina (Generalitat de Catalunya)
García-Altés, Anna (Institut d'Investigació Biomèdica Sant Pau)
De Batlle, Jordi (Hospital Universitari Arnau de Vilanova i Santa Maria)
Sánchez De-La-Torre, Manuel (Hospital Universitari Arnau de Vilanova i Santa Maria)
Barbé, Ferran (Hospital Universitari Arnau de Vilanova i Santa Maria)
Universitat Autònoma de Barcelona

Date:	2017
Abstract:	There are different phenotypes of obstructive sleep apnoea (OSA), many of which have not been characterised. Identification of these different phenotypes is important in defining prognosis and guiding the therapeutic strategy. The aim of this study was to characterise the entire population of continuous positive airway pressure (CPAP)-treated patients in Catalonia and identify specific patient profiles using cluster analysis. A total of 72,217 CPAP-treated patients who contacted the Catalan Health System (Cat-Salut) during the years 2012 and 2013 were included. Six clusters were identified, classified as "Neoplastic patients" (Cluster 1, 10. 4%), "Metabolic syndrome patients" (Cluster 2, 27. 7%), "Asthmatic patients" (Cluster 3, 5. 8%), "Musculoskeletal and joint disorder patients" (Cluster 4, 10. 3%), "Patients with few comorbidities" (Cluster 5, 35. 6%) and "Oldest and cardiac disease patients" (Cluster 6, 10. 2%). Healthcare facility use and mortality were highest in patients from Cluster 1 and 6. Conversely, patients in Clusters 2 and 4 had low morbidity, mortality and healthcare resource use. Our findings highlight the heterogeneity of CPAP-treated patients, and suggest that OSA is associated with a different prognosis in the clusters identified. These results suggest the need for a comprehensive and individualised approach to CPAP treatment of OSA.
Rights:	Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original.
Language:	Anglès
Document:	Article ; recerca ; Versió publicada
Published in:	PloS one, Vol. 12 Núm. 9 (september 2017) , p. e0185191, ISSN 1932-6203

DOI: 10.1371/journal.pone.0185191
PMID: 28934303

12 p, 3.4 MB

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Research literature > UAB research groups literature > Research Centres and Groups (research output) > Health sciences and biosciences > Institut de Recerca Sant Pau
Articles > Research articles
Articles > Published articles