Accuracy and prognostic impact of FDG PET/CT and biopsy in bone marrow assessment of follicular lymphoma at diagnosis : A Nation-Wide cohort study
Ródenas-Quiñonero, Isabel (H.J.M. Morales Meseguer (Múrcia))
Chen-Liang, Tzu (S. de Hematología y Oncología Médica. H.J.M. Morales Meseguer (Múrcia))
Martín Santos, Taida (Hospital Universitario de Canarias (La Laguna))
Salar, Antonio (Hospital del Mar (Barcelona, Catalunya))
Fernández-González, Marta (Hospital Universitario de Canarias (La Laguna))
Celades, Carolina (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras)
Navarro, José-Tomás (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras)
Martínez-Garcia, Ana Belén (Hospital Sta. Lucia)
Andreu, Rafael (Hospital Universitari i Politècnic La Fe (València))
Balaguer, Aitana (Hospital Universitari i Politècnic La Fe (València))
Martín García-Sancho, Alejandro (Hospital Clínico Universitario (Salamanca))
Baile, Mónica (Hospital Clínico Universitario (Salamanca))
Lopez-Jimenez, Javier (Hospital Universitario Ramón y Cajal (Madrid))
Marquet-Palomanes, Juan (Hospital Universitario Ramón y Cajal (Madrid))
Teruel, Ana Isabel (Hospital Clínic Universitari (València))
Terol, Maria Jose (Hospital Clínic Universitari (València))
Benet, Carmen (Hospital Arnau de Villanova (València))
Frutos, Laura (Hospital Universitario Virgen de la Arrixaca (Múrcia))
Navarro, José Luís (Hospital Universitario Virgen de la Arrixaca (Múrcia))
Uña-Gorospe, Jon (Hospital Universitario Nuestra Señora de Candelaria (Santa Cruz de Tenerife))
Suarez, Marina (Hospital del Mar (Barcelona, Catalunya))
Cortés, Montserrat A. (Hospital Universitari de Bellvitge)
Contreras, José (Hospital Santa Lucia)
Ruiz, Cristina (Hospital Universitari i Politècnic La Fe (València))
Tamayo, Pilar (Hospital Clínico Universitario (Salamanca))
Mucientes, Jorge (Hospital Puerta de Hierro (Madrid))
Sopena-Novales, Pablo (S. de Medicina Nuclear. Hospital 9 de Octubre)
Reguilón-Gallego, Laura (H.J.M. Morales Meseguer (Múrcia))
Sánchez-Blanco, José Javier (H.J.M. Morales Meseguer (Múrcia))
Pérez-Ceballos, Elena (H.J.M. Morales Meseguer (Múrcia))
Jerez, Andrés (Servicio de Hematología y Oncología Médica (Múrcia))
Ortuño, Francisco José (Servicio de Hematología y Oncología Médica (Múrcia))
Universitat Autònoma de Barcelona

Date:	2023
Abstract:	Backgound: In the workup of follicular lymphoma (FL), bone marrow biopsy (BMB) assessment is a key component of FLIPI and FLIPI2, the most widely used outcome scores. During the previous decade, several studies explored the role of FDG-PET/CT for detecting nodal and extranodal disease, with only one large study comparing both techniques. Methods: The aim of our study was to evaluate the diagnostic accuracy and the prognostic impact of both procedures in a retrospective cohort of 299 FL patients with both tests performed at diagnosis. In order to avoid a collinearity bias, FLIPI2 was deconstructed in its founding parameters, and the bone marrow involvement (BMI) parameter separately included as: a positive BMB, a positive PET/CT, the combined "PET/CT and BMB positive" or "PET/CT or BMB positive". These variables were also confronted independently with the POD24 in 233 patients treated with intensive regimens. Results: In the total cohort, bone marrow was involved in 124 and 60 patients by BMB and PET/CT, respectively. In terms of overall survival, age > 60 y. o. and the combined "PET/CT or BMB positive" achieved statistical independence as a prognostic factor. In patients treated with an intensive regimen, only the combined "PET/CT or BMB positive" added prognostic value for a shorter overall survival, when confronted with the POD24. Conclusion: Our results show that in FL both BMB and PET/CT should be considered at diagnosis, as their combined assessment provides independent prognostic value in the context of the most widely use clinical scores.
Rights:	Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original.
Language:	Anglès
Document:	Article ; recerca ; Versió publicada
Subject:	Bone marrow biopsy ; Follicular lymphoma ; PET/CT
Published in:	Cancer Medicine, Vol. 12 Núm. 6 (march 2023) , p. 6536-6546, ISSN 2045-7634

DOI: 10.1002/cam4.5424
PMID: 36373169

11 p, 673.6 KB

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Research literature > UAB research groups literature > Research Centres and Groups (research output) > Health sciences and biosciences > Institut d'Investigació en Ciencies de la Salut Germans Trias i Pujol (IGTP) > Josep Carreras Leukaemia Research Institute
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Articles > Published articles