Pan-cancer proteogenomics connects oncogenic drivers to functional states
Li, Yize (Washington University in St. Louis)
Porta-Pardo, Eduard (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras)
Tokheim, Collin (Harvard T.H. Chan School of Public Health)
Bailey, Matthew H. (Brigham Young University)
Yaron, Tomer (Weill Cornell Medicine)
Stathias, Vasileios (University of Miami Miller School of Medicine)
Geffen, Yifat (Massachusetts General Hospital)
Imbach, Kathleen (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras)
Cao, Song (McDonnell Genome Institute)
Anand, Shankara (Broad Institute of Massachusetts Institute of Technology and Harvard)
Akiyama, Yo (Broad Institute of Massachusetts Institute of Technology and Harvard)
Liu, Wenke (NYU Grossman School of Medicine)
Wyczalkowski, Matthew A. (McDonnell Genome Institute)
Song, Yizhe (McDonnell Genome Institute)
Storrs, Erik P. (McDonnell Genome Institute)
Wendl, Michael C. (Washington University in St. Louis)
Zhang, Wubing (Dana-Farber Cancer Institute (Boston, Estats Units))
Sibai, Mustafa (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras)
Ruiz-Serra, Victoria (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras)
Liang, Wen-Wei (McDonnell Genome Institute)
Terekhanova, Nadezhda V. (McDonnell Genome Institute)
Martins Rodrigues, Fernanda (McDonnell Genome Institute)
Clauser, Karl R. (Broad Institute of Massachusetts Institute of Technology and Harvard)
Heiman, David I. (Broad Institute of Massachusetts Institute of Technology and Harvard)
Zhang, Qing (Broad Institute of Massachusetts Institute of Technology and Harvard)
Aguet, Francois (Broad Institute of Massachusetts Institute of Technology and Harvard)
Calinawan, Anna Pamela (Icahn School of Medicine at Mount Sinai)
Dhanasekaran, Saravana Mohan (University of Michigan)
Birger, Chet (Broad Institute of Massachusetts Institute of Technology and Harvard)
Satpathy, Shankha (Broad Institute of Massachusetts Institute of Technology and Harvard)
Zhou, Daniel Cui (McDonnell Genome Institute)
Wang, Liang-Bo (McDonnell Genome Institute)
Baral, Jessika (McDonnell Genome Institute)
Johnson, Jared L. (Weill Cornell Medicine)
Huntsman, Emily M. (Weill Cornell Medicine)
Pugliese, Pietro (University of Sannio (Benevento, Itàlia))
Colaprico, Antonio (University of Miami Miller School of Medicine)
Iavarone, Antonio (University of Miami Miller School of Medicine)
Chheda, Milan G. (Washington University in St. Louis)
Ricketts, Christopher J. (National Institutes of Health (Bethesda, Estats Units d'Amèrica))
Fenyö, David (NYU Grossman School of Medicine)
Payne, Samuel H. (Brigham Young University)
Rodriguez, Henry (Office of Cancer Clinical Proteomics Research)
Robles, Ana I. (Office of Cancer Clinical Proteomics Research)
Gillette, Michael A. (Harvard Medical School)
Kumar-Sinha, Chandan (University of Michigan)
Lazar, Alexander (The University of Texas MD Anderson Cancer Center)
Cantley, Lewis (Weill Cornell Medicine)
Getz, Gad A. (Harvard Medical School)
Ding, Li (Siteman Cancer Center)
An, Eunkyung
Anurag, Meenakshi
Bavarva, Jasmin
Birrer, Michael J.
Ceccarelli, Michele
Chan, Daniel W.
Chinnaiyan, Arul M.
Cho, Hanbyul
Chowdhury, Shrabanti
Cieslik, Marcin P.
da Veiga Leprevost, Felipe
Day, Corbin
Domagalski, Marcin J.
Dou, Yongchao
Druker, Brian J.
Edwards, Nathan
Ellis, Matthew J.
Selvan, Myvizhi Esai
Foltz, Steven M.
Francis, Alicia
Gonzalez Robles, Tania J.
Gosline, Sara J. C.
Gümüş, Zeynep H.
Hiltke, Tara
Hong, Runyu
Hostetter, Galen
Hu, Yingwei
Huang, Chen
Huntsman, Emily
Jaehnig, Eric J.
Jewel, Scott D.
Ji, Jiayi
Jiang, Wen
Katsnelson, Lizabeth
Ketchum, Karen A.
Kolodziejczak, Iga
Lei, Jonathan T.
Liao, Yuxing
Lindgren, Caleb M.
Liu, Tao
Ma, Weiping
McKerrow, Wilson
Nesvizhskii, Alexey I.
Newton, Chelsea
Oldroyd, Robert
Omenn, Gilbert S.
Paulovich, Amanda G.
Petralia, Francesca
Reva, Boris
Rodland, Karin D.
Ruggles, Kelly V.
Rykunov, Dmitry
Savage, Sara R.
Schadt, Eric E.
Schnaubelt, Michael
Schraink, Tobias
Shi, Zhiao
Smith, Richard D.
Song, Xiaoyu
Tan, Jimin
Thangudu, Ratna R.
Tignor, Nicole
Wang, Joshua M.
Wang, Pei
Wang, Ying Cindy
Wen, Bo
Wiznerowicz, Maciej
Yi, Xinpei
Zhang, Bing
Zhang, Hui
Zhang, Xu
Zhang, Zhen
Universitat Autònoma de Barcelona

Fecha:	2023
Resumen:	Cancer driver events refer to key genetic aberrations that drive oncogenesis; however, their exact molecular mechanisms remain insufficiently understood. Here, our multi-omics pan-cancer analysis uncovers insights into the impacts of cancer drivers by identifying their significant cis-effects and distal trans-effects quantified at the RNA, protein, and phosphoprotein levels. Salient observations include the association of point mutations and copy-number alterations with the rewiring of protein interaction networks, and notably, most cancer genes converge toward similar molecular states denoted by sequence-based kinase activity profiles. A correlation between predicted neoantigen burden and measured T cell infiltration suggests potential vulnerabilities for immunotherapies. Patterns of cancer hallmarks vary by polygenic protein abundance ranging from uniform to heterogeneous. Overall, our work demonstrates the value of comprehensive proteogenomics in understanding the functional states of oncogenic drivers and their links to cancer development, surpassing the limitations of studying individual cancer types.
Ayudas:	Agencia Estatal de Investigación PID2019-107043RA-I00
Derechos:	Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, i la comunicació pública de l'obra, sempre que no sigui amb finalitats comercials, i sempre que es reconegui l'autoria de l'obra original. No es permet la creació d'obres derivades.
Lengua:	Anglès
Documento:	Article ; recerca ; Versió publicada
Materia:	CPTAC ; Cancer hallmark ; Oncogenic driver ; Pan-cancer ; Phosphoproteomics ; Protein complex ; Proteogenomics ; Proteomics ; Therapeutic target
Publicado en:	Cell, Vol. 186 Núm. 18 (31 2023) , p. 3921-3944.e25, ISSN 1097-4172

DOI: 10.1016/j.cell.2023.07.014
PMID: 37582357

50 p, 28.5 MB

El registro aparece en las colecciones:
Documentos de investigación > Documentos de los grupos de investigación de la UAB > Centros y grupos de investigación (producción científica) > Ciencias de la salud y biociencias > Institut d'Investigació en Ciencies de la Salut Germans Trias i Pujol (IGTP) > Instituto de Investigación contra la Leucemia Josep Carreras
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