Translational medicine in hereditary hemorrhagic telangiectasia
Riera Mestre, Antoni (Institut d'Investigació Biomèdica de Bellvitge)
Cerdà, Pau (Institut d'Investigació Biomèdica de Bellvitge)
Iriarte, Adriana (Institut d'Investigació Biomèdica de Bellvitge)
Graupera, Mariona (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras)
Viñals, Francesc (Institut d'Investigació Biomèdica de Bellvitge)

Date:	2022
Abstract:	Scientific community have gained lots of new insights in the genetic and biochemical background of different conditions, rare diseases included, settling the basis for preclinical models that are helping to identify new biomarkers and therapeutic targets. Translational Medicine (TM) is an interdisciplinary area of biomedicine with an essential role in bench-to-bedside transition enhancement, generating a circular flow of knowledge transference between research environment and clinical setting, always centered in patient needs. Here, we present different tools used in TM and an overview of what is being done related to hereditary hemorrhagic telangiectasia (HHT), as a disease's model. This work is focused on how this combination of basic and clinical research impacts in HHT patient's daily clinical management and also looking into the future. Further randomized clinical trials with HHT patients should assess the findings of this bench-to-bedside transition. The benefits of this basic and clinical research combination, may not only be important for HHT patients but for patients with other vascular diseases sharing angiogenic disturbances.
Grants:	Instituto de Salud Carlos III PI20/00592
Rights:	Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original.
Language:	Anglès
Document:	Ressenya ; recerca ; Versió publicada
Subject:	Hereditary hemorrhagic telangiectasia ; Translational medicine ; Angiogenesis ; Rare diseases
Published in:	European Journal of Internal Medicine, Vol. 95 (january 2022) , p. 32-37, ISSN 1879-0828

DOI: 10.1016/j.ejim.2021.09.003

6 p, 810.3 KB

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Research literature > UAB research groups literature > Research Centres and Groups (research output) > Health sciences and biosciences > Institut d'Investigació en Ciencies de la Salut Germans Trias i Pujol (IGTP) > Josep Carreras Leukaemia Research Institute
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