Feasibility and safety of low-flow extracorporeal carbon dioxide removal to facilitate ultra-protective ventilation in patients with moderate acute respiratory distress sindrome
Fanelli, Vito (Università di Torino)
Ranieri, Marco V. (Ospedale Policlinico Umberto I)
Mancebo, Jordi (Institut d'Investigació Biomèdica Sant Pau)
Moerer, Onnen (Universitätsmedizin Göttingen)
Quintel, Michael (Universitätsmedizin Göttingen)
Morley, Scott (ALung Technologies (Pittsburgh, Estats Units d'Amèrica))
Morán, Indalecio (Institut d'Investigació Biomèdica Sant Pau)
Parrilla-Gómez, Francisco José (Institut d'Investigació Biomèdica Sant Pau)
Costamagna, Andrea (Università di Torino)
Gaudiosi, Marco (Università di Torino)
Combes, Alain (Assistance Publique-Hopitaux de Paris)
Universitat Autònoma de Barcelona

Date:	2016
Abstract:	Mechanical ventilation with a tidal volume (V) of 6 mL/kg/predicted body weight (PBW), to maintain plateau pressure (P) lower than 30 cmHO, does not completely avoid the risk of ventilator induced lung injury (VILI). The aim of this study was to evaluate safety and feasibility of a ventilation strategy consisting of very low V combined with extracorporeal carbon dioxide removal (ECCOR). In fifteen patients with moderate ARDS, V was reduced from baseline to 4 mL/kg PBW while PEEP was increased to target a plateau pressure - (P) between 23 and 25 cmHO. Low-flow ECCOR was initiated when respiratory acidosis developed (pH < 7. 25, PaCO.
Rights:	Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original.
Language:	Anglès
Document:	Article ; recerca ; Versió publicada
Published in:	Critical care, Vol. 20 Núm. 1 (february 2016) , p. 36, ISSN 1466-609X

DOI: 10.1186/s13054-016-1211-y
PMID: 26861596

7 p, 504.8 KB

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Research literature > UAB research groups literature > Research Centres and Groups (research output) > Health sciences and biosciences > Institut de Recerca Sant Pau
Articles > Research articles
Articles > Published articles