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Concentrations of nitrogen compounds are related to severe rhinovirus infection in infants. A time-series analysis from the reference area of a pediatric university hospital in Barcelona
Armero, Georgina (Hospital Sant Joan de Déu. Pediatrics Intensive Care Unit)
Penela-Sánchez, Daniel (Hospital Sant Joan de Déu. Pediatrics Intensive Care Unit)
Belmonte, Jordina (Universitat Autònoma de Barcelona. Departament de Biologia Animal, de Biologia Vegetal i d'Ecologia)
Gómez-Barroso, Diana (Centro Nacional de Epidemiología (Espanya))
Larrauri, Amparo (Centro Nacional de Epidemiología (Espanya))
Henares Bonilla, Desiree (Instituto de Salud Carlos III.Centro de Investigación Biomédica en Red de Epidemiología y Salud Pública)
Vallejo, Violeta (Hospital Sant Joan de Déu. Pediatrics Department)
Jordán García, Iolanda (Universitat de Barcelona. Departament de Cirurgia i Especialitats Medicoquirúrgiques)
Muñoz-Almagro, Carmen (Universitat Internacional de Catalunya. Departament de Medicina)
Brotons de los Reyes, Pedro (Universitat Internacional de Catalunya. Departament de Medicina)
Launes, Cristian (Universitat de Barcelona. Departament de Cirurgia i Especialitats Medicoquirúrgiques)

Data: 2022
Resum: Background: There is scarce information focused on the effect of weather conditions and air pollution on specific acute viral respiratory infections, such as rhinovirus (RV), with a wide clinical spectrum of severity. Objective: The aim of this study was to analyze the association between episodes of severe respiratory tract infection by RV and air pollutant concentrations (NOx and SO2) in the reference area of a pediatric university hospital. Methods: An analysis of temporal series of daily values of NOx and SO2, weather variables, circulating pollen and mold spores, and daily number of admissions in the pediatric intensive care unit (PICU) with severe respiratory RV infection (RVi) in children between 6 months and 18 years was performed. Lagged variables for 0-5 days were considered. The study spanned from 2010 to 2018. Patients with comorbidities were excluded. Results: One hundred and fifty patients were admitted to the PICU. Median age was 19 months old (interquartile range [IQR]: 11-47). No relationship between RV-PICU admissions and temperature, relative humidity, cumulative rainfall, or wind speed was found. Several logistic regression models with one pollutant and two pollutants were constructed but the best model was that which included average daily NOx concentrations. Average daily NOx concentrations were related with the presence of PICU admissions 3 days later (odds ratio per IQR-unit increase: 1. 64, 95% confidence interval: 1. 20-2. 25)). Conclusions: This study has shown a positive correlation between NOx concentrations at Lag 3 and children's PICU admissions with severe RV respiratory infection. Air pollutant data should be taken into consideration when we try to understand the severity of RVis.
Ajuts: Instituto de Salud Carlos III PI17/349
Instituto de Salud Carlos III FI17/00248
Drets: Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, i la comunicació pública de l'obra, sempre que no sigui amb finalitats comercials, i sempre que es reconegui l'autoria de l'obra original. No es permet la creació d'obres derivades. Creative Commons
Llengua: Anglès
Document: Article ; recerca ; Versió publicada
Matèria: Air pollutants ; Intensive care units ; Respiratory tract disease ; Rhinovirus ; Virus infections
Publicat a: Pediatric Pulmonology, Vol. 57, Issue 9 (September 2022) , p. 2180-2188, ISSN 1099-0496

DOI: 10.1002/ppul.26021
PMID: 35652447


9 p, 997.7 KB

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 Registre creat el 2024-02-29, darrera modificació el 2024-05-18



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