Head and neck cancers survival in Europe, Taiwan, and Japan : results from RARECAREnet Asia based on a privacy-preserving federated infrastructure
Botta, Laura (Department of Epidemiology and Data Science. Fondazione IRCCS Istituto Nazionale dei Tumori)
Matsuda, Tomohiro (Insititute of Cancer Control. National Cancer Center (Japò))
Charvat, Hadrien (National Cancer Center (Japò))
Chiang, Chung-Ju (Taiwan Cancer Registry Center)
Lee, Wen-Chung (Taiwan Cancer Registry Center)
van Gestel, Anna Jacoba (Department of Research & Development. Netherlands Comprehensive Cancer Organisation)
Martin, Frank (Department of Research & Development. Netherlands Comprehensive Cancer Organisation)
Geleijnse, Gijs (Department of Research & Development. Netherlands Comprehensive Cancer Organisation)
Cellamare, Mattheo (Department of Research & Development. Netherlands Comprehensive Cancer Organisation)
Bonfarnuzzo, Simone (Department of Epidemiology and Data Science. Fondazione IRCCS Istituto Nazionale dei Tumori)
Marcos-Gragera, Rafael (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras)
Guevara, Marcela (Instituto de Investigación Sanitaria de Navarra)
Mousavi, Mohsen (East Switzerland Cancer Registry)
Craig, Stefano (Queen's University Belfast)
Rodrigues, Jessica (Porto Comprehensive Cancer Centre (Portugal))
Rubió-Casadevall, Jordi (Institut de Recerca Biomèdica de Lleida)
Licitra, Lisa (Department of Oncology and Hemato-Oncology. University of Milan)
Cavalieri, Stephanie (Department of Oncology and Hemato-Oncology. University of Milan)
Resteghini, Carlo (Fondazione IRCCS Istituto Nazionale dei Tumori di Milano)
Gatta, Gemma (Fondazione IRCCS Istituto Nazionale dei Tumori di Milano)
Trama, Annalisa (Fondazione IRCCS Istituto Nazionale dei Tumori di Milano)

Data:	2023
Resum:	Background: The head and neck cancers (HNCs) incidence differs between Europe and East Asia. Our objective was to determine whether survival of HNC also differs between European and Asian countries. Methods: We used population-based cancer registry data to calculate 5-year relative survival (RS) for the oral cavity, hypopharynx, larynx, nasal cavity, and major salivary gland in Europe, Taiwan, and Japan. We modeled RS with a generalized linear model adjusting for time since diagnosis, sex, age, subsite, and histological grouping. Analyses were performed using federated learning, which enables analyses without sharing sensitive data. Findings: Five-year RS for HNC varied between geographical areas. For each HNC site, Europe had a lower RS than both Japan and Taiwan. HNC subsites and histologies distribution and survival differed between the three areas. Differences between Europe and both Asian countries persisted even after adjustments for all HNC sites but nasal cavity and paranasal sinuses, when comparing Europe and Taiwan. Interpretation: Survival differences can be attributed to different factors including different period of diagnosis, more advanced stage at diagnosis, or different availability/access of treatment. Cancer registries did not have stage and treatment information to further explore the reasons of the observed survival differences. Our analyses have confirmed federated learning as a feasible approach for data analyses that addresses the challenges of data sharing and urge for further collaborative studies including relevant prognostic factors.
Nota:	The Taiwan cancer registry was funded by the Health Promotion Administration, Ministry of Health and Welfare of Taiwan, grant no. A1101009: Tobacco Health and Welfare Taxation. TM and HC were supported for the present manuscript and received grants from the "Health and Labor Sciences Research Grant (20EA1026)". FM was supported for the present manuscript by the "Netherlands Comprehensive Cancer Organisation". This research was funded by the Italian Ministry of Health "Ricerca Corrente" funds. The funders had no role in study design, data collection and analysis, interpretation of data, writing of the report, and the decision to submit the paper for publication.
Drets:	Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original.
Llengua:	Anglès
Document:	Article ; recerca ; Versió publicada
Matèria:	Population-based cancer registry ; Survival ; Geographical differences ; Federated learning approach survival ; Head and neck cancers ; Federated learning approach
Publicat a:	Frontiers in Oncology, Vol. 13 (2023) , p. 1219111, ISSN 2234-943X

DOI: 10.3389/fonc.2023.1219111
PMID: 37781187

8 p, 715.4 KB

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Documents de recerca > Documents dels grups de recerca de la UAB > Centres i grups de recerca (producció científica) > Ciències de la salut i biociències > Institut d'Investigació en Ciencies de la Salut Germans Trias i Pujol (IGTP) > Institut de Recerca contra la Leucèmia Josep Carreras
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