Defensive-lipid droplets : Cellular organelles designed for antimicrobial immunity
Safi, Rémi (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras)
Sánchez-Álvarez, Miguel (Instituto de Investigaciones Biomédicas "Alberto Sols")
Bosch, Marta (Universitat de Barcelona)
Demangel, Caroline (Université Paris Cité, France)
Parton, Robert G. (University of Queensland, Australia)
Pol, Albert (Institució Catalana de Recerca i Estudis Avançats)

Date:	2023
Abstract:	Microbes have developed many strategies to subvert host organisms, which, in turn, evolved several innate immune responses. As major lipid storage organelles of eukaryotes, lipid droplets (LDs) are an attractive source of nutrients for invaders. Intracellular viruses, bacteria, and protozoan parasites induce and physically interact with LDs, and the current view is that they "hijack" LDs to draw on substrates for host colonization. This dogma has been challenged by the recent demonstration that LDs are endowed with a protein-mediated antibiotic activity, which is upregulated in response to danger signals and sepsis. Dependence on host nutrients could be a generic "Achilles' heel" of intracellular pathogens and LDs a suitable chokepoint harnessed by innate immunity to organize a front-line defense. Here, we will provide a brief overview of the state of the conflict and discuss potential mechanisms driving the formation of the 'defensive-LDs' functioning as hubs of innate immunity.
Grants:	European Commission 953489 Agencia Estatal de Investigación PID2021-128106NA-I00 Agencia Estatal de Investigación PID2021-127043OB-I00
Rights:	Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, i la comunicació pública de l'obra, sempre que no sigui amb finalitats comercials, i sempre que es reconegui l'autoria de l'obra original. No es permet la creació d'obres derivades.
Language:	Anglès
Document:	Article de revisió ; recerca ; Versió publicada
Subject:	Bacteria ; Innate immunity ; Interferon ; Lipid droplets ; Parasites ; Virus
Published in:	Immunological Reviews, Vol. 317 Núm. 1 (august 2023) , p. 113-136, ISSN 1600-065X

DOI: 10.1111/imr.13199

24 p, 4.0 MB

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Research literature > UAB research groups literature > Research Centres and Groups (research output) > Health sciences and biosciences > Institut d'Investigació en Ciencies de la Salut Germans Trias i Pujol (IGTP) > Josep Carreras Leukaemia Research Institute
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Articles > Published articles