Current Approach in the Management of Secondary Immunodeficiency in Patients with Hematological Malignancies : Spanish Expert Consensus Recommendations
Boqué, Concepción (Hospital Duran i Reynals (Hospitalet del Llobregat))
Sánchez-Ramón, Silvia (Hospital Clínico San Carlos (Madrid))
Cordoba, Raul (Department of Hematology. Hospital Universitari Fundación Jimenez Diaz)
Moreno, Carol (Institut d'Investigació Biomèdica Sant Pau)
Cabezudo, Elena (ICO-Hospital de Sant Joan Despí Moisès Broggi)

Data:	2023
Resum:	A Delphi-based survey was designed to assess the opinions of clinical hematologists (n = 17) and clinical immunologists (n = 18) from across Spain on secondary immunodeficiencies (SID) in the management of oncohematological patients. There was 100% agreement on the need to have available guidelines for the management of immunodeficiency in hematological patients; to perform a baseline immunological evaluation in patients with chronic lymphocytic leukemia (CLL), multiple myeloma (MM), lymphoma and hematopoietic stem cell transplantation (HSCT) recipients; and to quantify serum IgG, IgA and IgM levels when SID is suspected. More than 90% agreed on the need for active immunization against seasonal influenza and H1N1, pneumococcus and Haemophilus influenzae. There was a consensus on the monitoring of IgG levels every 3 months (83%) and the need to have available a clinical protocol for the use of IVIG in the management of SID (94%), to monitor trough IgG levels to determine the correct IVIG dose (86%) and to discontinue IVIG after the recovery of IgG levels after 12 months of follow-up (77%). The findings of the present survey may be useful recommendations for hematologists and immunologists to improve the management of SID in daily practice.
Ajuts:	Instituto de Salud Carlos III PI19/00753
Nota:	This research was funded by Grifols. The sponsors had no role in the design, execution, interpretation or writing of the survey. Research grants were obtained from Instituto de Salud Carlos III (FIS PI19/00753 to C.M) and from Deutsche José Carreras Leukämie Stiftung e.V.
Drets:	Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original.
Llengua:	Anglès
Document:	Article ; recerca ; Versió publicada
Matèria:	Secondary immunodeficiency ; B-cell lymphoproliferative disorders (BCLPD) ; Infections ; Hypogammaglobulinemia ; Intravenous IgG
Publicat a:	Journal of clinical medicine, Vol. 12 Núm. 19 (october 2023) , p. 6356, ISSN 2077-0383

DOI: 10.3390/jcm12196356
PMID: 37835000

14 p, 670.4 KB

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