Pericytes in the disease spotlight
van Splunder, Hielke (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras)
Villacampa, Pilar (Institut d'Investigació Biomèdica de Bellvitge)
Martínez-Romero, Anabel (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras)
Graupera, Mariona (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras)

Date:	2024
Abstract:	Pericytes are known as the mural cells in small-caliber vessels that interact closely with the endothelium. Pericytes play a key role in vasculature formation and homeostasis, and when dysfunctional contribute to vasculature-related diseases such as diabetic retinopathy and neurodegenerative conditions. In addition, significant extravascular roles of pathological pericytes are being discovered with relevant implications for cancer and fibrosis. Pericyte research is challenged by the lack of consistent molecular markers and clear discrimination criteria versus other (mural) cells. However, advances in single-cell approaches are uncovering and clarifying mural cell identities, biological functions, and ontogeny across organs. We discuss the latest developments in pericyte pathobiology to inform future research directions and potential outcomes.
Grants:	Ministerio de Ciencia e Innovación RYC2020-029929-I
Rights:	Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, i la comunicació pública de l'obra, sempre que no sigui amb finalitats comercials, i sempre que es reconegui l'autoria de l'obra original. No es permet la creació d'obres derivades.
Language:	Anglès
Document:	Ressenya ; recerca ; Versió publicada
Published in:	Trends in Cell Biology, Vol. 34 Núm. 1 (january 2024) , p. 58-71, ISSN 1879-3088

DOI: 10.1016/j.tcb.2023.06.001
PMID: 37474376

14 p, 2.1 MB

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Research literature > UAB research groups literature > Research Centres and Groups (research output) > Health sciences and biosciences > Institut d'Investigació en Ciencies de la Salut Germans Trias i Pujol (IGTP) > Josep Carreras Leukaemia Research Institute
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