Cancer Incidence in Heart Transplant Recipients with Previous Neoplasia History
Delgado-Jiménez, Juan Francisco (Hospital 12 de Octubre (Madrid))
Alonso-Pulpón, L. (Hospital Universitario Puerta de Hierro Majadahonda (Madrid))
Mirabet Pérez, Sonia (Institut d'Investigació Biomèdica Sant Pau)
Almenar Bonet, Luis (Hospital Universitari i Politècnic La Fe (València))
Pérez-Villa, Félix (Hospital Clínic i Provincial de Barcelona)
González-Vílchez, Francisco (Hospital Universitario Marqués de Valdecilla (Santander, Cantabria))
Palomo, J. (Hospital General Universitario Gregorio Marañón)
Blasco-Peiro, Teresa (Hospital Universitario Miguel Servet (Saragossa))
Dolores García-Cosio, M. (Hospital 12 de Octubre (Madrid))
González-Costello, J. (Hospital Universitari de Bellvitge)
de la Fuente Galán, Luis (Hospital Clínico Universitario de Valladolid)
Rábago Juan-Aracil, Gregorio (Clínica Universidad de Navarra)
Lage, E. (Hospital Universitario Virgen del Rocío (Sevilla, Andalusia))
Pascual-Figal, Domingo Andrés (Hospital Universitario Virgen de la Arrixaca (Múrcia))
Díaz-Molina, Beatriz (Hospital Universitario Central de Asturias)
Arizón, J. M (Hospital Universitario Reina Sofía (Córdoba, Espanya))
Muñiz, Javier (Instituto Universitario de Ciencias de la Salud Instituto de Investigacion Biomedica de A Coruna. Universidade da Coruña)
Crespo-Leiro, Maria Generosa (Complejo Hospitalario Universitario de A Coruña)
Universitat Autònoma de Barcelona

Date:	2016
Abstract:	Neoplasm history increases morbidity and mortality after solid organ transplantation and has disqualified patients from transplantation. Studies are needed to identify factors to be considered when deciding on the suitability of a patient with previous tumor for heart transplantation. A retrospective epidemiological study was conducted in heart transplant (HT) recipients (Spanish Post-Heart Transplant Tumor Registry) comparing the epidemiological data, immu-nosuppressive treatments and incidence of post-HT tumors between patients with previous malignant noncardiac tumor and with no previous tumor (NPT). The impact of previous tumor (PT) on overall survival (OS) was also assessed. A total of 4561 patients, 77 PT and 4484 NPT, were evaluated. The NPT group had a higher proportion of men than the PT group (p < 0. 001). The incidence of post-HT tumors was 1. 8 times greater in the PT group (95% confidence interval [CI] 1. 2-2. 6; p < 0. 001), mainly due to the increased risk in patients with a previous hematologic tumor (rate ratio 2. 3, 95% CI 1. 3-4. 0, p < 0. 004). OS during the 10-year posttransplant period was significantly lower in the PT than the NPT group (p = 0. 048) but similar when the analysis was conducted after a first post-HT tumor was diagnosed. In conclusion, a history of PT increases the incidence of post-HT tumors and should be taken into account when considering a patient for HT.
Rights:	Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, i la comunicació pública de l'obra, sempre que no sigui amb finalitats comercials, i sempre que es reconegui l'autoria de l'obra original. No es permet la creació d'obres derivades.
Language:	Anglès
Document:	Ressenya ; recerca ; Versió publicada
Published in:	American Journal of Transplantation, Vol. 16 Núm. 5 (january 2016) , p. 1569-1578, ISSN 1600-6143

DOI: 10.1111/ajt.13637
PMID: 26613555

10 p, 203.8 KB

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