Gene co-expression architecture in peripheral blood in a cohort of remitted first-episode schizophrenia patients
Rodríguez, Natalia (Institut d'investigacions Biomèdiques August Pi i Sunyer (IDIBAPs))
Gassó, Patricia (Centro de Investigación Biomédica en Red en Salud Mental)
Martínez-Pinteño, Albert (Institut d'investigacions Biomèdiques August Pi i Sunyer (IDIBAPs))
Segura, Àlex-González (Institut d'investigacions Biomèdiques August Pi i Sunyer (IDIBAPs))
Mezquida, Gisela (Hospital Clínic i Provincial de Barcelona)
Moreno-Izco, Lucia (Instituto de Investigación Sanitaria de Navarra)
González-Peñas, Javier (Centro de Investigación Biomédica en Red de Salud Mental)
Zorrilla, Iñaki (Universidad del País Vasco)
Martin, Marta (Institut d'Investigació Biomèdica Sant Pau)
Rodriguez-Jimenez, Roberto (Universidad Complutense de Madrid)
Corripio, Iluminada (Universitat Autònoma de Barcelona)
Sarró, Salvador (Universitat Internacional de Catalunya)
Ibáñez, Angela (Hospital Universitario Ramón y Cajal)
Butjosa, Anna (Hospital Sant Joan de Déu (Manresa))
Contreras, Fernando (Centro de Investigación Biomédica en red en salud Mental (CIBERSAM))
Bioque, Miquel (Universitat de Barcelona)
Cuesta, Manuel-Jesús (Hospital General Universitario Gregorio Marañón)
Parellada, Mara (Centro de Investigación Biomédica en Red de Salud Mental)
González-Pinto, Ana (Universidad del País Vasco)
Berrocoso, Esther (Instituto de Investigación e Innovación Biomédica de Cádiz)
Bernardo, Miquel (Universitat de Barcelona)
Mas, Sergi (Centro de Investigación Biomédica en red en salud Mental (CIBERSAM))
Amoretti S, Silvia (Hospital Clínic i Provincial de Barcelona)
Moren, Constanza (Centro deInvestigación Biomédica en Red (CIBER) de Enfermedades Raras (CIBERER))
Stella, Carol (Centro de Investigación Biomédica en Red de Salud Mental)
Gurriarán, Xaquin (Centro de Investigación Biomédica en Red de Salud Mental)
Alonso-Solís, Anna (Universitat Autònoma de Barcelona)
Grasa, Eva (Universitat Autònoma de Barcelona)
Fernandez, Jessica (Universidad del País Vasco)
Gonzalez-Ortega, Itxaso (Universidad del País Vasco)
Casanovas, Francesc (Institut Hospital del Mar d'Investigacions Mèdiques)
Bulbuena, Antoni (Universitat Autònoma de Barcelona)
Núñez-Doyle, Ágatha (Instituto de Investigación Sanitaria Hospital 12 de Octubre (i+12))
Jiménez-Rodríguez, Olga (Instituto de Investigación Sanitaria Hospital 12 de Octubre (i+12))
Pomarol-Clotet, Edith (Centro de Investigación Biomédica en Red de Salud Mental)
Feria-Raposo, Isabel (Benito Menni CASM)
Usall, Judith (Institut de Recerca Sant Joan de Déu)
Muñoz-Samons, Daniel (Hospital Materno-Infantil Sant Joan de Déu)
Ilundain, Jose L. (Instituto de Investigación Sanitaria de Navarra)
Sánchez-Torres, Ana Maria (Instituto de Investigación Sanitaria de Navarra)
Saiz-Ruiz, Jeronimo (Universidad de Alcalá)
López-Torres, Isabel (Hospital Universitario Ramón y Cajal)
Nacher, Juan (Instituto de Investigación Sanitaria INCLIVA (València, Comunitat Valenciana))
De-la-Cámara, Concepción (Centro de Investigación Biomédica en red en salud Mental (CIBERSAM))
Gutiérrez, Miguel (Arabako Unibertsitate Ospitalea (Vitoria, País Basc))
Sáiz, Pilar Alejandra (Instituto de Investigación Sanitaria del Principado de Asturias)

Date:	2022
Abstract:	A better understanding of schizophrenia subtypes is necessary to stratify the patients according to clinical attributes. To explore the genomic architecture of schizophrenia symptomatology, we analyzed blood co-expression modules and their association with clinical data from patients in remission after a first episode of schizophrenia. In total, 91 participants of the 2EPS project were included. Gene expression was assessed using the Clariom S Human Array. Weighted-gene co-expression network analysis (WGCNA) was applied to identify modules of co-expressed genes and to test its correlation with global functioning, clinical symptomatology, and premorbid adjustment. Among the 25 modules identified, six modules were significantly correlated with clinical data. These modules could be clustered in two groups according to their correlation with clinical data. Hub genes in each group showing overlap with risk genes for schizophrenia were enriched in biological processes related to metabolic processes, regulation of gene expression, cellular localization and protein transport, immune processes, and neurotrophin pathways. Our results indicate that modules with significant associations with clinical data showed overlap with gene sets previously identified in differential gene-expression analysis in brain, indicating that peripheral tissues could reveal pathogenic mechanisms. Hub genes involved in these modules revealed multiple signaling pathways previously related to schizophrenia, which may represent the complex interplay in the pathological mechanisms behind the disease. These genes could represent potential targets for the development of peripheral biomarkers underlying illness traits in clinical remission stages after a first episode of schizophrenia.
Grants:	Ministerio de Ciencia e Innovación PI11/00325 Ministerio de Economía y Competitividad PI14/00612
Rights:	Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original.
Language:	Anglès
Document:	Article ; recerca ; Versió publicada
Published in:	Schizophrenia, Vol. 8 Núm. 1 (december 2022) , p. 45, ISSN 2754-6993

DOI: 10.1038/s41537-022-00215-1
PMID: 35853879

9 p, 871.1 KB

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Research literature > UAB research groups literature > Research Centres and Groups (research output) > Health sciences and biosciences > Institut de Recerca Sant Pau
Articles > Research articles
Articles > Published articles