Long-Term Risk of Breast Cancer after Diagnosis of Benign Breast Disease by Screening Mammography
Román, Marta (Institut Hospital del Mar d'Investigacions Mèdiques)
Louro, Javier (Institut Hospital del Mar d'Investigacions Mèdiques)
Posso, Margarita (Institut Hospital del Mar d'Investigacions Mèdiques)
Vidal, Carmen (Institut Catala d'Oncologia)
Bargalló, Xavier (Hospital Clínic i Provincial de Barcelona)
Vázquez, Ivonne (Institut Hospital del Mar d'Investigacions Mèdiques)
Quintana Ruiz, Maria Jesús (Institut d'Investigació Biomèdica Sant Pau)
Alcántara Souza, Rodrigo (Institut Hospital del Mar d'Investigacions Mèdiques)
Saladié, Francina (Hospital Universitari Sant Joan de Reus)
del Riego, Javier (Parc Taulí Hospital Universitari. Institut d'Investigació i Innovació Parc Taulí (I3PT))
Peñalva, Lupe (Hospital Asil de Granollers Private Foundation)
Sala, Maria (Institut Hospital del Mar d'Investigacions Mèdiques)
Castells, Xavier (Institut Hospital del Mar d'Investigacions Mèdiques)
Universitat Autònoma de Barcelona

Date:	2022
Abstract:	Assessing the long-term risk of breast cancer after diagnosis of benign breast disease by mammography is of utmost importance to design personalised screening strategies. We analysed individual-level data from 778,306 women aged 50-69 years with at least one mammographic screening participation in any of ten breast cancer screening centers in Spain from 1996 to 2015, and followed-up until 2017. We used Poisson regression to compare the rates of incident breast cancer among women with and without benign breast disease. During a median follow-up of 7. 6 years, 11,708 (1. 5%) women had an incident of breast cancer and 17,827 (2. 3%) had a benign breast disease. The risk of breast cancer was 1. 77 times higher among women with benign breast disease than among those without (95% CI: 1. 61 to 1. 95). The relative risk increased to 1. 99 among women followed for less than four years, and remained elevated for two decades, with relative risk 1. 96 (95% CI: 1. 32 to 2. 92) for those followed from 12 to 20 years. Benign breast disease is a long-term risk factor for breast cancer. Women with benign breast disease could benefit from closer surveillance and personalized screening strategies.
Grants:	Ministerio de Economía y Competitividad PI15/00098 Ministerio de Economía y Competitividad RD16/0001/0013 Instituto de Salud Carlos III PI17/00047
Rights:	Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original.
Language:	Anglès
Document:	Article ; recerca ; Versió publicada
Subject:	Benign breast disease ; Breast neoplasms ; Longitudinal studies ; Mass screening
Published in:	International journal of environmental research and public health, Vol. 19 Núm. 5 (3-1 2022) , p. 2625, ISSN 1660-4601

DOI: 10.3390/ijerph19052625
PMID: 35270331

11 p, 1.3 MB

The record appears in these collections:
Research literature > UAB research groups literature > Research Centres and Groups (research output) > Health sciences and biosciences > Parc Taulí Research and Innovation Institute (I3PT
Research literature > UAB research groups literature > Research Centres and Groups (research output) > Health sciences and biosciences > Institut de Recerca Sant Pau
Articles > Research articles
Articles > Published articles