Metabolic network alterations as a supportive biomarker in dementia with Lewy bodies with preserved dopamine transmission
Stockbauer, Anna (German Center for Neurodegenerative Diseases)
Beyer, Leonie (University Hospital, LMU Munich)
Huber, Maria (University Hospital, LMU Munich)
Kreuzer, Annika (University Hospital, LMU Munich)
Palleis, Carla (Munich Cluster for Systems Neurology)
Katzdobler, Sabrina (Munich Cluster for Systems Neurology)
Rauchmann, Boris-Stephan (University Hospital, LMU Munich)
Morbelli, Silvia (University of Genoa)
Chincarini, Andrea (National Institute of Nuclear Physics)
Bruffaerts, Rose (University of Antwerp)
Vandenberghe, Rik (University Hospitals Leuven (Bèlgica))
Kramberger, Milica G. (University Medical Centre)
Trost, Maja (Univerza V Ljubljani)
Garibotto, Valentina (Geneva University)
Nicastro, Nicolas (Geneva University Hospitals)
Lathuilière, Aurélien (Geneva University Hospitals)
Lemstra, Afina W. (Vrije Universiteit Amsterdam)
van Berckel, Bart N. M. (Vrije Universiteit Amsterdam)
Pilotto, Andrea (University of Brescia)
Padovani, Alessandro (University of Brescia)
Ochoa-Figueroa, Miguel A. (Linköping University)
Davidsson, Anette (Linköping University)
Camacho, Valle (Institut d'Investigació Biomèdica Sant Pau)
Peira, Enrico (University of Genoa)
Bauckneht, Matteo (IRCCS Ospedale Policlinico San Martino)
Pardini, Matteo (IRCCS Ospedale Policlinico San Martino)
Sambuceti, Gianmario (University of Genoa)
Aarsland, Dag (King's College)
Nobili, Flavio (IRCCS Ospedale Policlinico San Martino)
Gross, Mattes (University Hospital, LMU Munich)
Vöglein, Jonathan (German Center for Neurodegenerative Diseases)
Perneczky, Robert (Imperial College)
Pogarell, Oliver (University Hospital, LMU Munich)
Buerger, Katharina (University of Munich)
Franzmeier, Nicolai (German Center for Neurodegenerative Diseases)
Danek, Adrian (German Center for Neurodegenerative Diseases)
Levin, Johannes (Munich Cluster for Systems Neurology)
Höglinger, Günter U. (Munich Cluster for Systems Neurology)
Bartenstein, Peter (Munich Cluster for Systems Neurology)
Cumming, Paul (Queensland University of Technology)
Rominger, Axel (University of Bern)
Brendel, Matthias (Munich Cluster for Systems Neurology)
Universitat Autònoma de Barcelona

Fecha:	2023
Resumen:	Metabolic network analysis of FDG-PET utilizes an index of inter-regional correlation of resting state glucose metabolism and has been proven to provide complementary information regarding the disease process in parkinsonian syndromes. The goals of this study were (i) to evaluate pattern similarities of glucose metabolism and network connectivity in dementia with Lewy bodies (DLB) subjects with subthreshold dopaminergic loss compared to advanced disease stages and to (ii) investigate metabolic network alterations of FDG-PET for discrimination of patients with early DLB from other neurodegenerative disorders (Alzheimer's disease, Parkinson's disease, multiple system atrophy) at individual patient level via principal component analysis (PCA). FDG-PETs of subjects with probable or possible DLB (n = 22) without significant dopamine deficiency (z -score < 2 in putamen binding loss on DaT-SPECT compared to healthy controls (HC)) were scaled by global-mean, prior to volume-of-interest-based analyses of relative glucose metabolism. Single region metabolic changes and network connectivity changes were compared against HC (n = 23) and against DLB subjects with significant dopamine deficiency (n = 86). PCA was applied to test discrimination of patients with DLB from disease controls (n = 101) at individual patient level. Similar patterns of hypo- (parietal- and occipital cortex) and hypermetabolism (basal ganglia, limbic system, motor cortices) were observed in DLB patients with and without significant dopamine deficiency when compared to HC. Metabolic connectivity alterations correlated between DLB patients with and without significant dopamine deficiency (R 2 = 0. 597, p < 0. 01). A PCA trained by DLB patients with dopamine deficiency and HC discriminated DLB patients without significant dopaminergic loss from other neurodegenerative parkinsonian disorders at individual patient level (area-under-the-curve (AUC): 0. 912). Disease-specific patterns of altered glucose metabolism and altered metabolic networks are present in DLB subjects without significant dopaminergic loss. Metabolic network alterations in FDG-PET can act as a supporting biomarker in the subgroup of DLB patients without significant dopaminergic loss at symptoms onset. The online version contains supplementary material available at 10. 1007/s00259-023-06493-w.
Derechos:	Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original.
Lengua:	Anglès
Documento:	Article ; recerca ; Versió publicada
Materia:	DaT-Scan ; Dementia with Lewy bodies ; FDG-PET ; Metabolic connectivity
Publicado en:	European Journal of Nuclear Medicine and Molecular Imaging, Vol. 51 (november 2023) , p. 1023-1034, ISSN 1619-7089

DOI: 10.1007/s00259-023-06493-w
PMID: 37971501

12 p, 3.1 MB

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