Exploring the influence of circulating endocannabinoids and nucleus accumbens functional connectivity on anorexia nervosa severity
Miranda-Olivos, Romina (Hospital Universitari de Bellvitge)
Baenas Soto, Isabel Maria (Hospital Universitari de Bellvitge)
Steward, Trevor (University of Melbourne, Australia)
Granero, Roser (Universitat Autònoma de Barcelona. Departament de Psicobiologia i de Metodologia de les Ciències de la Salut)
Pastor, Antoni (Centro de Investigación Biomédica en Red de Fisiopatología de la Obesidad y Nutrición)
Sánchez Díaz, Isabel María (Hospital Universitari de Bellvitge)
Juaneda-Seguí, Asier (Universitat de Barcelona)
Del Pino Gutiérrez, Amparo (Centro de Investigación Biomédica en Red de Fisiopatología de la Obesidad y Nutrición)
Fernandez Formoso, Jose Antonio (Centro de Investigación Biomédica en Red de Fisiopatología de la Obesidad y Nutrición)
Vilarrasa, Nuria (Hospital Universitari de Bellvitge)
Guerrero-Pérez, Fernando (Hospital Universitari de Bellvitge)
Virgili, Nuria (Hospital Universitari de Bellvitge)
López-Urdiales, Rafael (Hospital Universitari de Bellvitge)
Jiménez Murcia, Susana (Hospital Universitari de Bellvitge)
De La Torre, Rafael (Centro de Investigación Biomédica en Red de Fisiopatología de la Obesidad y Nutrición)
Soriano-Mas, Carles (Centro de Investigación Biomédica en Red de Salud Mental)
Fernández Aranda, Fernando (Hospital Universitari de Bellvitge)

Data:	2023
Descripció:	8 pàg.
Resum:	Anorexia nervosa (AN) is a severe psychiatric disorder characterized by a harmful persistence of self-imposed starvation resulting in significant weight loss. Research suggests that alterations in the nucleus accumbens (NAcc) and circulating endocannabinoids (eCBs), such as anandamide (AEA) and 2-arachidonoylglycerol (2-AG), may contribute to increased severity and maladaptive behaviors in AN, warranting an examination of the interplay between central reward circuitry and eCBs. For this purpose, we assessed NAcc functional connectivity and circulating AEA and 2-AG concentrations in 18 individuals with AN and 18 healthy controls (HC) to test associations between circulating eCBs, NAcc functional connectivity, and AN severity, as defined by body mass index (BMI). Decreased connectivity was observed between the NAcc and the right insula (NAcc-insula; p < 0. 001) and the left supplementary motor area (NAcc-SMA; p < 0. 001) in the AN group compared to HC. Reduced NAcc-insula functional connectivity mediated the association between AEA concentrations and BMI in the AN group. However, in HC, NAcc-SMA functional connectivity had a mediating role between AEA concentrations and BMI. Although no significant differences in eCBs concentrations were observed between the groups, our findings provide insights into how the interaction between eCBs and NAcc functional connectivity influences AN severity. Altered NAcc-insula and NAcc-SMA connectivity in AN may impair the integration of interoceptive, somatosensory, and motor planning information related to reward stimuli. Furthermore, the distinct associations between eCBs concentrations and NAcc functional connectivity in AN and HC could have clinical implications for weight maintenance, with eCBs being a potential target for AN treatment.
Ajuts:	Instituto de Salud Carlos III PI20/00132 Agencia Estatal de Investigación PID2021-124887OB-I00 Agència de Gestió d'Ajuts Universitaris i de Recerca 2021/SGR-00824 European Commission 847879 European Commission 101080219 Instituto de Salud Carlos III CM21/00172
Nota:	Altres ajuts: This manuscript and research were co-funded by FEDER funds/European Regional Development Fund (ERDF), a way to build Europe. Additional support was received from the Delegación del Gobierno para el Plan Nacional sobre Drogas (2021I031). This work was partially supported by Instituto de Salud Carlos III through the grant CM21/00172 (IB) (co-funded by European Social Fund. ESF investing in your future). RG is supported by the Catalan Institution for Research and Advanced Studies (ICREA-Academia, 2021-Programme). TS is supported by a National Health and Medical Research Council (NHMRC)/Medical Research Future Fund (MRFF) Investigator Grant (MRF1193736), a Brain & Behavior Research Foundation (BBRF) Young Investigator Grant, and a University of Melbourne McKenzie Fellowship.
Drets:	Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original.
Llengua:	Anglès
Document:	Article ; recerca ; Versió publicada
Matèria:	Neuroscience ; Psychiatric disorders ; Anorexia nervosa
Publicat a:	Molecular psychiatry, Vol. 28 (september 2023) , p. 4793-4800, ISSN 1476-5578

DOI: 10.1038/s41380-023-02253-2
PMID: 37759041

8 p, 1.1 MB

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