Single carbon metabolism - A new paradigm for microbial bioprocesses?
Baumschabl, Michael (Austrian Centre of Industrial Biotechnology (ACIB))
Ata, Özge (Austrian Centre of Industrial Biotechnology (ACIB))
Mattanovich, Diethard (Austrian Centre of Industrial Biotechnology (ACIB))

Date:	2024
Abstract:	Increasing atmospheric carbon dioxide levels, a reduction of arable land area and the dependence of first and second generation biotechnology feedstocks on agricultural products, call for alternative, sustainable feedstock sources for industrial applications. The direct use of CO2 or conversion of CO2 into other single carbon (C1) sources have great potential as they might help to reduce carbon emissions and do not compete with agricultural land use. Here we discuss the microbial use of C1 carbon sources, their potential applications in biotechnology, and challenges towards sustainable C1-based industrial biotechnology processes. We focus on methanol, formic acid, methane, syngas, and CO2 as feedstocks for bioprocesses, their assimilation pathways, current and emerging applications, and limitations of their application. This mini-review is intended as a first introduction for researchers who are new to the field of C1 biotechnology.
Grants:	European Commission 101000441
Rights:	Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, i la comunicació pública de l'obra, sempre que no sigui amb finalitats comercials, i sempre que es reconegui l'autoria de l'obra original. No es permet la creació d'obres derivades.
Language:	Anglès
Document:	Article ; recerca ; Versió publicada
Subject:	Sustainability ; Bioeconomy ; Carbon dioxide ; Methanol ; Formate ; Methane
Published in:	Synthetic and Systems Biotechnology, Vol. 9, Issue 2 (June 2024) , p. 322-329, ISSN 2405-805X

DOI: 10.1016/j.synbio.2024.03.003
PMID: 38545459

8 p, 3.3 MB

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