Asthma patients' and physicians' perspectives on the burden and management of asthma : Post-hoc analysis of APPaRENT 1 and 2 to assess predictors of treatment adherence
Canonica, Giorgio Walter (Humanitas University, Asthma & Allergy Unit IRCCS, Humanitas Research Hospital, Milan, Italy)
Domingo, Christian (Universitat Autònoma de Barcelona. Departament de Medicina)
Lavoie, Kim L. (University of Quebec at Montreal and Montreal Behavioural Medicine Centre, CIUSSS-NIM, Hopital du Sacre-Coeur de Montreal, Canada)
Kaliasethi, Amrit (Avalere Health, Fleet, UK)
Khan, Shireen Quli (GSK, Global Medical Affairs, General Medicines, Dubai, United Arab Emirates)
Majumdar, Anurita (GSK, Global Medical Affairs, General Medicines, Singapore)
Fulmali, Sourabh (GlaxoSmithKline (Mumbai, Índia))

Data:	2024
Resum:	Introduction: Patient adherence to maintenance medication is critical for improving clinical outcomes in asthma and is a recommended guiding factor for treatment strategy. Previously, the APPaRENT studies assessed patient and physician perspectives on asthma care; here, a post-hoc analysis aimed to identify patient factors associated with good adherence and treatment prescription patterns. Methods: APPaRENT 1 and 2 were cross-sectional online surveys of 2866 adults with asthma and 1883 physicians across Argentina, Australia, Brazil, Canada, China, France, Italy, Mexico, and the Philippines in 2020-2021. Combined data assessed adherence to maintenance medication, treatment goals, use of asthma action plans, and physician treatment patterns and preferences. Multivariable logistic regression models assessed associations between patient characteristics and both treatment prescription (by physicians) and patient treatment adherence. Results: Patient and physician assessments of treatment goals and adherence differed, as did reporting of short-acting β-agonist (SABA) prescriptions alongside maintenance and reliever therapy (MART). Older age and greater patient-reported severity and reliever use were associated with better adherence. Patient-reported prescription of SABA with MART was associated with household smoking, severe or poorly controlled asthma, and living in China or the Philippines. Conclusions: Results revealed an important disconnect between patient and physician treatment goals and treatment adherence, suggesting that strategies for improving patient adherence to maintenance medication are needed, focusing on younger patients with milder disease. High reliever use despite good adherence may indicate poor disease control. Personalised care considering patient characteristics alongside physician training in motivational communication and shared decision-making could improve patient management and outcomes.
Nota:	Altres ajuts: GSK (Study IDs: 212911 and 214325)
Drets:	Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original.
Llengua:	Anglès
Document:	Article ; recerca ; Versió publicada
Matèria:	3-6): Treatment adherence ; Inhalation therapy ; Physician-patient relations ; Patient engagement
Publicat a:	Respiratory Medicine, Vol. 227 (april 2024) , ISSN 1532-3064

DOI: 10.1016/j.rmed.2024.107637

8 p, 2.3 MB

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