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| Pàgina inicial > Articles > Articles publicats > Reduced graphene oxide electrodes meet lateral flow assays : |
(Institut Català de Nanociència i Nanotecnologia) (Institut Català de Nanociència i Nanotecnologia) (Institut Català de Nanociència i Nanotecnologia) (Institut Català de Nanociència i Nanotecnologia)| Data: | 2024 |
| Resum: | Research in electrochemical detection in lateral flow assays (LFAs) has gained significant momentum in recent years. The primary impetus for this surge in interest is the pursuit of achieving lower limits of detection, especially given that LFAs are the most widely employed point-of-care biosensors. Conventionally, the strategy for merging electrochemistry and LFAs has centered on the superposition of screen-printed electrodes onto nitrocellulose substrates during LFA fabrication. Nevertheless, this approach poses substantial limitations regarding scalability. In response, we have developed a novel method for the complete integration of reduced graphene oxide (rGO) electrodes into LFA strips. We employed a CO laser to concurrently reduce graphene oxide and pattern nitrocellulose, exposing its backing to create connection sites impervious to sample leakage. Subsequently, rGO and nitrocellulose were juxtaposed and introduced into a roll-to-roll system using a wax printer. The exerted pressure facilitated the transfer of rGO onto the nitrocellulose. We systematically evaluated several electrochemical strategies to harness the synergy between rGO and LFAs. While certain challenges persist, our rGO transfer technology presents compelling potential for setting a new standard in electrochemical LFA fabrication. |
| Ajuts: | Agencia Estatal de Investigación PID2021-124795NB-I00 Agencia Estatal de Investigación PRE2018-084856 Agència de Gestió d'Ajuts Universitaris i de Recerca 2021/SGR-01464 Agencia Estatal de Investigación CEX2021-001214-S European Commission 881603 European Commission 101029884 European Commission 101120706 |
| Drets: | Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original.  |
| Llengua: | Anglès |
| Document: | Article ; recerca ; Versió publicada |
| Matèria: | Electrochemistry ; Lateral flow assays ; Laser reduced graphene oxide ; Scalable fabrication ; Nanoflowers |
| Publicat a: | Biosensors & bioelectronics, Vol. 258 (August 2024) , art. 116315, ISSN 1873-4235 |
