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| Página principal > Artículos > Artículos publicados > Differences in macular vessel density in the superficial plexus across cognitive impairment : |
(Instituto de Salud Carlos III) (Instituto de Salud Carlos III) (Universitat Internacional de Catalunya. Ace Alzheimer Center Barcelona) (Instituto de Salud Carlos III) (Parc de Salut MAR de Barcelona) (Universitat Autònoma de Barcelona. Departament de Cirurgia) (Universitat Internacional de Catalunya. Ace Alzheimer Center Barcelona) (Universitat Internacional de Catalunya. Ace Alzheimer Center Barcelona) (Universitat Internacional de Catalunya. Ace Alzheimer Center Barcelona) (Instituto de Salud Carlos III) (Instituto de Salud Carlos III) (Instituto de Salud Carlos III) (Instituto de Salud Carlos III) (Universitat Internacional de Catalunya. Ace Alzheimer Center Barcelona) (Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas) (Instituto de Salud Carlos III) (Instituto de Salud Carlos III)
| Fecha: | 2022 |
| Resumen: | Optical coherence tomography angiography (OCT-A) allows the detection of retinal vessel density (VD) loss, which is a reflection of brain vascular pathology. We aimed to investigate differences in macular VD in the superficial plexus in a large cohort of individuals cognitively unimpaired (CU), with mild cognitive impairment due to Alzheimer's disease (MCI-AD), MCI due to cerebrovascular pathology (MCI-Va), probable Alzheimer's disease dementia (ADD) and Vascular Dementia (VaD). Clinical, demographical, ophthalmological and OCT-A data from the Neuro-ophthalmology Research at Fundació ACE (NORFACE) project were analyzed. Differences of macular VD in four quadrants (superior, nasal, inferior and temporal) among the five diagnostic groups were assessed in a multivariate regression model, adjusted by age, sex, education, hypertension, diabetes mellitus, heart disease and stroke. The study cohort comprised 672 participants: 128 CU, 120 MCI-AD, 111 MCI-Va, 257 ADD and 56 VaD. Regression analysis showed a significantly higher VD in the temporal quadrant in MCI-AD compared to CU participants (49. 05 ± 4. 91 vs 47. 27 ± 4. 17, p = 0. 02, d = 0. 40), and a significantly lower VD in the inferior quadrant in MCI-Va compared to CU participants (48. 70 ± 6. 57 vs 51. 27 ± 6. 39, p = 0. 02, d = 0. 40). Individuals with heart disease presented significantly lower VD in the inferior quadrant than those without (p = 0. 01). The interaction of sex and diagnosis had no effect in differentiating VD. Mini-Mental State Examination (MMSE) scores were not correlated to VD (all r < 0. 16; p > 0. 07). In conclusion, our study showed that the MCI-AD and MCI-Va groups had significant differences in macular VD in opposite directions in the temporal and inferior quadrants, respectively, compared to CU participants, suggesting that macular VD might be able to differentiate two pathogenic pathways (AD- and cerebrovascular-related) in early stages of cognitive decline. |
| Ayudas: | Instituto de Salud Carlos III PI19/00335 Instituto de Salud Carlos III PI17/01474 Instituto de Salud Carlos III AC17/00100 Instituto de Salud Carlos III PI19/01301 Instituto de Salud Carlos III AC19/00097 |
| Derechos: | Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original.  |
| Lengua: | Anglès |
| Documento: | Article ; recerca ; Versió publicada |
| Materia: | Alzheimer Disease ; Cognitive Dysfunction ; Copper ; Fluorescein Angiography ; Heart Diseases ; Humans ; Retinal Vessels ; Tomography, Optical Coherence |
| Publicado en: | Scientific reports, Vol. 12 Núm. 1 (december 2022) , p. 16938, ISSN 2045-2322 |
